重组小鼠BTN1A1(嗜乳脂蛋白亚家族1成员A1)

特别提示：包括重组小鼠BTN1A1(嗜乳脂蛋白亚家族1成员A1)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组小鼠BTN1A1(嗜乳脂蛋白亚家族1成员A1)
英文名称：Recombinant Mouse Butyrophilin Subfamily 1 Member A1
产品货号：JN1621
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Ala27-Trp247在C端含有His标签。

BTN1A1/Butyrophilin质量控制：＞95%(还原性SDS-PAGE)

BTN1A1/Butyrophilin制剂：冻干品

BTN1A1/Butyrophilin保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

BTN1A1/Butyrophilin复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于BTN1A1/Butyrophilin：
Mouse Butyrophilin subfamily 1 member A1(BTN1A1) is a type I transmembrane glycoprotein which is a member of the Ig superfamily. The BTN1A1 ECD displays two predicted IgV and IgC domains as do B7 and Skint proteins which interact with other Ig superfamily members. BTN1A1 binds to xanthine oxidoreductase (XOR). This interaction stabilizes the association of XOR with the milk fat globule membrane and appears to be essential in the control of milk fat globule secretion. In vitro, BTN1A1 inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL-2 and IFN-γ secretion. Furthermore, in vivo, BTN1A1 has a protective effect against the development of experimental autoimmune encephalomyelitis (EAE). Because butyrophilins are structurally related to B7 proteins and are functionally implicated in immune regulation, they may represent an emerging family of costimulatory/inhibitory molecules.

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