not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
85kDa
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human G6PDH
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: H6PD (hexose-6-phosphate dehydrogenase, GDH/6PGL endoplasmic bifunctional protein) is a 789 amino acid protein encoded by the human gene H6PD. The N-terminal section of H6PD belongs to the glucose-6-phosphate dehydrogenase family, while the C-terminal section belongs to the glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily. H6PD is responsible primarily for the oxidation of glucose-6-phosphate and glucose. It also oxidizes other hexose-6-phosphates. H6PD catalyzes the conversion of glucose 6-phosphate to 6-phosphogluconolactone within the lumen of the endoplasmic reticulum, thereby generating reduced nicotinamide adenine dinucleotide phosphate. Reduced nicotinamide adenine dinucleotide phosphate is a necessary cofactor for the reductase activity of 11∫-hydroxysteroid dehydrogenase type 1, which converts hormonally inactive cortisone to active cortisol (in rodents, 11-dehydrocorticosterone to corticosterone).
Function: Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
Tissue Specificity: Present in most tissues examined, strongest in liver.
DISEASE: Defects in H6PD are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
Similarity: In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family. In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Database links:
Entrez Gene: 25796 Human
Entrez Gene: 9563 Human
Entrez Gene: 100198 Mouse
Entrez Gene: 66171 Mouse
Entrez Gene: 290636 Rat
Entrez Gene: 298655 Rat
Omim: 138090 Human
Omim: 604951 Human
SwissProt: O95336 Human
SwissProt: O95479 Human
SwissProt: Q8CFX1 Mouse
SwissProt: Q9CQ60 Mouse
SwissProt: P85971 Rat
Unigene: 463511 Human
Unigene: 466165 Human
Unigene: 22183 Mouse
Unigene: 282284 Mouse
Unigene: 402679 Mouse
Unigene: 17292 Rat
Unigene: 19855 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.