重组人GAMT(胍基乙酸N-甲基转移酶)

特别提示：包括重组人GAMT(胍基乙酸N-甲基转移酶)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人GAMT(胍基乙酸N-甲基转移酶)
英文名称：Recombinant Human Guanidinoacetate N-methyltransferase

产品货号：重组人GAMT(胍基乙酸N-甲基转移酶)
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Gly236在N端、C端都带有His标签。

GAMT质量控制：＞95%(还原性SDS-PAGE)

GAMT制剂：液体

GAMT保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于GAMT：
GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.

除了重组人GAMT(胍基乙酸N-甲基转移酶),，我公司还供应以下相关产品：



名称：重组小鼠PGF(胎盘生长因子)(带His标签)
货号：JN0260
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Val19-Pro158在C端含有His标签。

PGF质量控制：＞95%(还原性SDS-PAGE)。

PGF制剂：冻干品

PGF保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

PGF复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于PGF：
Placental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF/VEGF growth factor family. The protein is a member of the VEGF (vascular endothelial growth factor) sub-family-a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast.

名称：重组小鼠RANK(TNFRSF11A)(CD265)
货号：JN0509
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Val31-Ser214在C端含有His标签。

RANK/TNFRSF11A/CD265质量控制：＞95%(还原性SDS-PAGE)

RANK/TNFRSF11A/CD265制剂：冻干品

RANK/TNFRSF11A/CD265保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

RANK/TNFRSF11A/CD265复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于RANK/TNFRSF11A/CD265：
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member oftumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, brain and kidney, but weakly expressed in spleen and bone marrow. After binding its ligand RANKL, RANK can activate signaling pathways such as NF-κB, JNK, ERK, p38, and Akt/PKB, through TRAF protein phosphorylation. RANK/TNFRSF11A signaling is largely considered to be growth promoting and apoptosis reducing such as the effects observed in osteoclasts. RANK/TNFRSF11A was also found to be involved in the regulation of interactions between T-cells and dendritic cells.