名称:重组人醛酮还原酶家族1成员C2(AKR1C2) 分子生物学试剂 品牌:百奥莱博 英文名:Recombinant Human Aldo-Keto Reductase Family 1 Member C2 编号:JN0698 产地:国产|进口 规格:10μg|50μg|500μg|1mg 本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Tyr323表达纯化得来。
AKR1C2质量控制:>95%(还原性SDS-PAGE)
AKR1C2制剂:液体
AKR1C2保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于AKR1C2: Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation of the most potent androgen 5-α-Dihydrotestosterone (5-α-DHT) to 5-α-Androstane-3-α, 17-β-diol (3-α-diol).
关于IL-22: Interleukin-22 (IL-22) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid residue protein with a putative 33 amino acid signal peptide that is cleaved to generate a 147 amino acid mature protein that shares approximately 79% and 22% sequence identity with human IL22 and IL10, respectively. IL22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and up-regulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10Rβ (previously known as CRF2-4), belonging to the class II cytokine receptor family.
关于Cathepsin B/Ctsb: Cathepsin B (CatB) is an enzymatic protein belonging to the peptidase (or protease) families. which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis。