Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
Endothelin-1 (ET-1) is the predominant isoform of the endothelins, a family of endothelium-derived vasoconstrictor peptides. Endothelin-1 is expressed as a 212-aa precursor (preproendothelin-1) that is sequentially cleaved into 2 chains: Endothelin-1 (21 aa) and Big Endothelin-1 (38 aa). Big endothelin-1 is cleaved to yield endothelin-1 via the activity of an endothelin-converting enzyme (ECE), chymases and non-ECE metalloproteases. ET-1 exerts various biological effects, including vasoconstriction and the stimulation of cell proliferation in tissues via ET receptors A and B.
序列:
Human: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Cys1-Cys15, Cys3-Cys11) or H-CSCSSLMDKECVYFCHLDIIW-OH (Cys1-Cys15, Cys3-Cys11)
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
溶解方法:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
保存方法:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.