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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Flagecidin; Wuningmeisu C
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
22862-76-6
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥312.0 |
| 规格： | 10 mg | 产品价格： | ￥500.0 |
| 规格： | 50 mg | 产品价格： | ￥1000.0 |
| 规格： | 100 mg | 产品价格： | ￥1800.0 |
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Anisomycin
CAS No. : 22862-76-6
MCE 国际站：Anisomycin
产品活性：Anisomycin 是一种有效的蛋白质合成抑制剂，通过抑制肽基转移酶 80 核糖体系统干扰蛋白质和 DNA 合成。Anisomycin 是一种 JNK 激活剂，可增强磷酸化 JNK 。Anisomycin 是一种细菌抗生素。
研究领域：Cell Cycle/DNA Damage | MAPK/ERK Pathway | Anti-infection | Apoptosis
作用靶点：DNA/RNA Synthesis | JNK | Bacterial | Apoptosis | Antibiotic | Parasite
In Vitro: To examine whether JNK has a core role in colistin-induced neurotoxicity in PC-12 cells, an SP600125 (a highly selective inhibitor of JNK) and Anisomycin (a potent activator) are used in this study. In order to select an appropriate concentration, PC-12 cells are treated with a range of SP600125 (0-80 μM) and Anisomycin (0-20 μM) respectively for 24 h. The results show that the cells viability significantly decreases by SP600125 treatment in a concentration-dependent manner, observed at the concentrations greater than 20 μM (p<0.01). Similarly the cells viability is inhibited by Anisomycin treatment (≥8 μM) (p<0.05) .
In Vivo: Anisomycin (60 mg/kg; for 4-week continuous intravenous administration) significantly decreases mouse body weight in a dose-related manner, compared with the control group. Anisomycin (15 mg/kg; for 4-week continuous intravenous administration) slightly and transiently decreases the mouse body weight. There is no significant difference of the mouse body weight in 5 mg/kg group.
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文献和实验Activation of SAPKs/JNKs and p38s In Vitro
Anisomycin (6 ) SAPK/JNK, p38 All cells 1–10 μg/mL, 1–60 min UV-C (12
STANDARD PLANT MOLECULAR BIOLOGY PROTOCOLS
.6 H20 76.3 71.3 61.3 47.9 21.3 10x TBE 5.0 > > > > 10% APS 0.7 > >
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