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- 详细信息
- 技术资料
- 库存：
大量
- 供应商：
上海研卉生物科技有限公司
- 英文名：
Recombinant Human Stem Cell Factor
- 规格：
10μg
重组大鼠干细胞因子，Recombinant Rat SCF
SCF is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. The human SCF gene encodes for a 273 amino acid transmembrane protein, which contains a 25 amino acid N-terminal signal sequence, a 189 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 36 amino acid cytoplasmic domain. The secreted soluble form of SCF is generated by proteolytic processing of the membrane anchored precursor. Recombinant Rat SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.
Source: E.coli
Synonyms: Stem Cell Factor, c-Kit Ligand, Mast Cell Growth Factor (MGF), Steel Factor
AA Sequence: MQEICRNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV THLSVSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVAC MEENAPKNVK ESLKKPETRN FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by the dose-dependent stimulation of the proliferation of the human TF-1 cells. The expected ED50 for this effect is 20 - 40 ng/ml.
| First Author | Title | Citation | Date | Pubmed |
|---|---|---|---|---|
| Kobune, M | Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N',N"-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo. | Cancer Research; 61(13) pg5116-25 | 1 Jul 2001 | 11431349 Show Usages |
| Yamauchi, A | Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain. | The Journal of Biological Chemistry; 280(2) pg953-64 | 14 Jan 2005 | 15504745 Show Usages |
| Andrade, R M | TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. | Journal of immunology (Baltimore, Md. : 1950); 175(9) pg6014-21 | 1 Nov 2005 | 16237096 Show Usages |
| Khanna-Gupta, A | Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene. | Blood; 109(10) pg4181-90 | 15 May 2007 | 17244686 Show Usages |
| Yang, L | Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. | Blood; 110(12) pg3853-61 | 1 Dec 2007 | 17702896 Show Usages |
| Kobune, M | Adenoviral vector-mediated transfer of the Indian hedgehog gene modulates lymphomyelopoiesis in vivo. | Stem cells (Dayton, Ohio); 26(2) pg534-42 | 0 Feb 2008 | 17962696 Show Usages |
| Gan, B | mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. | Proceedings of the National Academy of Sciences of the United States of America; 105(49) pg19384-9 | 9 Dec 2008 | 19052232 Show Usages |
| Tipping, A J | High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. | Blood; 113(12) pg2661-72 | 19 Mar 2009 | 19168794 Show Usages |
| Stokman, G | Stem cell factor expression after renal ischemia promotes tubular epithelial survival. | PLoS ONE; 5(12) pge14386 | 21 Dec 2010 | 21200435 Show Usages |
| Pronk, C J | Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors. | The Journal of Experimental Medicine; 208(8) pg1563-70 | 1 Aug 2011 | 21768269 Show Usages |
| Khanna-Gupta, A | Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia. | The Journal of Biological Chemistry; 287(39) pg32728-37 | 21 Sep 2012 | 22851180 Show Usages |
| Rangel, E B | Kidney-derived c-kit | Scientific Reports; 8(1) pg14723 | 3 Oct 2018 | 30283057 Show Usages |
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