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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 供应商：
上海研卉生物科技有限公司
- 英文名：
Recombinant Rat M-CSF
- 规格：
10μg
Recombinant Rat M-CSF
Product Details
M-CSF is a potent hematopoietic factor produced by a variety of cells, including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages, and their respective progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness and fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. Human M-CSF is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant Rat M-CSF is a 36.2 kDa homodimeric protein consisting of two 155 amino acid polypeptide subunits.
Source: E.coli
Synonyms: Macrophage Colony Stimulating Factor, CSF-1, MGI-IM
AA Sequence (monomer): MEVSEHCSHM IGNGHLQILQ QLIDSQMETA CLIEYKFVDQ EQLDDPVCYL KKAFVLVQVI IEETMRFKDN TPNANATERL QELSMKLNSC FIKDYKEQNE ACVQTYKESP LRLLEKIKNF FNETKNFLEK DWNIFSKNCN DSLAKCSSRD VVTKP
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ≤ 5.0 ng/ml, corresponding to a specific activity of ≥ 2 x 105 units/mg.
| First Author | Title | Citation | Date | Pubmed |
|---|---|---|---|---|
| Gelati, M | The angiogenic response of the aorta to injury and inflammatory cytokines requires macrophages. | Journal of immunology (Baltimore, Md. : 1950); 181(8) pg5711-9 | 15 Oct 2008 | 18832730 Show Usages |
| Shang, X | R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. | The Journal of Biological Chemistry; 286(27) pg24068-78 | 8 Jul 2011 | 21572048 Show Usages |
| Ejlerskov, P | NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages. | The Journal of Biological Chemistry; 287(7) pg4835-52 | 10 Feb 2012 | 22157766 Show Usages |
| Anjubault, T | Constitutive expression of TNF-related activation-induced cytokine (TRANCE)/receptor activating NF-κB ligand (RANK)-L by rat plasmacytoid dendritic cells. | PLoS ONE; 7(3) pge33713 | 0 2012 | 22428075 Show Usages |
| Xue, L | Effects and interaction of icariin, curculigoside, and berberine in er-xian decoction, a traditional chinese medicinal formula, on osteoclastic bone resorption. | Evidence-based complementary and alternative medicine : eCAM; 2012 pg490843 | 0 2012 | 23243450 Show Usages |
| Lobato-Pascual, A | Rat macrophage C-type lectin is an activating receptor expressed by phagocytic cells. | PLoS ONE; 8(2) pge57406 | 0 2013 | 23468983 Show Usages |
| Madeira, M H | Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury. | Translational research : the journal of laboratory and clinical medicine; 169 pg112-28 | 0 Mar 2016 | 26685039 Show Usages |
| Petersen, M A | Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. | Neuron; 96(5) pg1003-1012.e7 | 6 Dec 2017 | 29103804 Show Usages |
| Li, J | VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism. | Nature Communications; 8(1) pg1322 | 6 Nov 2017 | 29109438 Show Usages |
| Kim, S J | Anti-inflammatory effect of Tauroursodeoxycholic acid in RAW 264.7 macrophages, Bone marrow-derived macrophages, BV2 microglial cells, and spinal cord injury. | Scientific Reports; 8(1) pg3176 | 16 Feb 2018 | 29453346 Show Usages |
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文献和实验The Generation of Plasmacytoid and Conventional Dendritic Cells with M-CSF
. We found that DC development could be driven from BM cells of FL knockout mice using the myeloid growth factor M-CSF. The M-CSF-driven DC (MDC) developed independently of FL and resembled the DC types present in the spleen in the steady state.
There is an increasing interest in the preparation of rat � rat hybridomas, because they have been found to be more stable in culture than mouse hybridomas and they secrete consistently high levels (10 �g/mL and above) of monoclonal antibody
The first transgenic experiment was carried out more than 15 yr ago, and transgenesis is now a routine technique for the study of gene and cell function, and the development of animal models of disease. The mouse remains the species of choice
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