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- .peprotech
- 400-06
- Recombinant Rat IL-6
- 2025年11月02日
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- 库存：
400-06
- 英文名：
Recombinant Rat Interleukin-6
- 规格：
10ug
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Rat IL-6 is a 21.7 kDa protein containing 188 amino acid residues.
Source: E.coli
Synonyms: 26 kDa protein, IFN-beta2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2
AA Sequence: MFPTSQVRRG DFTEDTTHNR PVYTTSQVGG LITYVLREIL EMRKELCNGN SDCMNSDDAL SENNLKLPEI QRNDGCFQTG YNQEICLLKI CSGLLEFRFY LEFVKNNLQD NKKDKARVIQ SNTETLVHIF KQEIKDSYKI VLPTPTSNAL LMEKLESQKE WLRTKTIQLI LKALEEFLKV TMRSTRQT
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is < 0.01 ng/ml, corresponding to a specific activity of > 1 x 108 units/mg.
Calculated Molecular Weight: 21.7 kDa
Accession Number: P20607
Gene ID: 24498
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文献和实验Pristane-Induced Arthritis in the Rat
A chronic relapsing arthritis develops after a single subcutaneous injection of small amounts of pristane; the pristane induced arthritis (PIA) model in the rat. PIA is characterized by a sudden onset of disease 2 wk after induction. The main
一、用途本试剂盒用于定量检测大鼠血清中的IL-6的浓度。二、原理本试剂盒采用双抗夹心ELISA法。抗大鼠IL-6单抗包被于酶标板上，大鼠标本中的IL-6会与单抗结合。加入生物素化的抗大鼠IL-6（二抗），它将与结合在单抗上的大鼠IL-6结合而形成免疫复合物，未结合的将被洗去。辣根过氧化物酶标记的Streptavidin 将与二抗的生物素结合，多余的物质会被洗掉。加入TMB显色。大鼠IL-6的浓度与OD(450nm)成正比。三、试剂盒组成酶标板(Coated Wells)48wellsAnti
图上查出相应 IL-6 含量。 试剂盒性能 1. 灵敏度 ： 最小的 IL-6 检测浓度小于 16pg/ml 。 2. 特异性： 可同时检测重组或天然的大鼠 IL-6 。 不与 大鼠其它细胞因子有交叉反应。 3. 重复性：板内、板见变异系数均小于10 ％。 注意事项 1. 以上标准孔及待测样品均建议做复孔，每次测定应同时做标准曲线。
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