Transient receptor potential cation channel, subfamily C, member 4, also known as TRPC4, is a human gene encoding a protein of the same name. They are expressed in smooth muscle and endothelial cells where they regulate membrane potential and calcium influx. TrpC4 is activated by G(q)/phospholipase C-coupled receptors, but the underlying mechanism remains elusive (1). Studies suggest TrpC4 contributes to axonal regeneration after nerve injury (2).
参考资料
1. Otsuguro K., et al. (2008) J Biol Chem. 283(15): 10026-10036. 2. Wu D., Huang W., Richardson P.M., Pristly J.V., Liu M. (2008) J. Biol. Chem. 283(1): 416-426.