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- 详细信息
- 文献和实验
- 技术资料
- 库存:
352
- 英文名:
Recombinant Human CD40 Ligand
- 保质期:
长期
- 供应商:
北京百奥莱博科技有限公司
- 保存条件:
冻干蛋白置于-20℃
- 规格:
10μg|50μg|500μg|1mg
特别提示:包括重组人CD40 Ligand(TNFSF5)在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!
产品名称:重组人CD40 Ligand(TNFSF5)
英文名称:Recombinant Human CD40 Ligand
产品货号:JN0452
产品规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Met113-Leu261表达纯化得来。
CD40 Ligand/TNFSF5质量控制:>95%(还原性SDS-PAGE)
CD40 Ligand/TNFSF5制剂:冻干品
CD40 Ligand/TNFSF5保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
CD40 Ligand/TNFSF5复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于CD40 Ligand/TNFSF5:
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.
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文献和实验白细胞分化抗原及其功能 CD40L 即CDl54分子,属于TNFSF成员,为Ⅱ型膜蛋白。 人CD40L主要表达在活化的CD4+T细胞以及部分CD8+T细胞和YaT细胞。此外,CD40L还表达于活化的嗜碱粒细胞、肥大细胞、NK细胞、某些单核细胞以及活化B细胞。静止淋巴细胞不表达CD40L。CD40L往往以三聚体形式结合三聚体的CD40分子(TNFR超家族成员)发挥生物学作用,即传递B细胞活化的第二信号(见第九章)。缺少第二
in their discovery. Recently, a nomenclature committee has adopted and promoted a simplified naming system; each member is designated tumor necrosis factor super family, TNFSF, with a numerical suffix. Thus, for example, TNF-α becomes TNFSF2 and Fas ligand
Biochemical Analysis of the Native TRAIL Death-Inducing Signaling Complex
-inducing capacity of a member of the TNFRSF relies on the presence of a death domain (DD) in the intracellular portion of the receptor protein. Such receptors are also referred to as death receptors. Binding of a TNFSF ligand to a TNFRSF receptor
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