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- SignalChem
- 加拿大
- A06-58B-1000
- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
1 mg
存储温度：Store product at –20oC. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
存储溶液：The peptide supplied in trifluroacetate salt as a lyophilized powder.
参考文献：1. Esler WP, et al: Stereochemical specificity of Alzheimer's disease beta-peptide assembly. Biopolymers. 1999 May;49(6):505-14. 2. Roher AE, et al: beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc Natl Acad Sci U S A. 1993 Nov 15;90 (22):10836-40.
官网链接：https://www.signalchem.com/product_details.php?id=6232
商品关键词：Amyloid beta 42 (E22G), Arctic Mutant,A06-58B-1000,SignalChem
简单描述：The synthetic Amyloid beta 42 Peptide (DAEFRHDSGY EVHHQKLVFF AGDVGSNKGA IIGLMVGGVV IA) is derived from human amyloid beta (amino acid 1-42).
Purity: The purity was determined to be >95% by HPLC analysis. Molecular Weight: The theoretical molecular weight is 4442.04 Scientific Background: Amyloid peptides, derived from amyloid precursor protein (APP), are thought to play a role in the development of the senile plaques associated with Alzheimer’s Disease. The amyloid hypothesis presupposes that flaws in the processing of APP result in abnormally high levels of the longer, “stickier” forms of beta amyloid, known as Abeta42 and Abeta43, leading to aggregation of amyloid in the neuronal cell death and ultimately neuronal death. Mutations in the structure of Abeta40 and related peptides as well as in some of the enzymes involved in the processing of APP have been shown to alter the processing of APP. The sporadic (i.e., non-genetic) form of the disease, however, is far more common, caused by aging in concert with a number of both genetic and environmental risk factors.
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文献和实验，Tiffany HL，Tumanov A，et al．Amyloid (beta) 42 activates a G-protein-coupled chemoattractant receptor，FPR-like-1．J Neurosci，2001，21:RC123．
. Impairments of long-term potentiation in hipocampal slices of β-amyloid-infused rats[J]. Eur J Pharmacol,1999,382(3):167-75. [5] Nakamara S , Murayama N , Noshita T et al . Progressive brain dysfunction following intracerebroventricular infusion of beta 1～42
Genetic and Pharmacologic Models for Type 1 Diabetes
‐negative effects of a novel mutated Ins2 allele causes early‐onset diabetes and severe beta‐cell loss in Munich Ins2C95S mutant mice. Diabetes 56: 1268‐ 1276. Hong, E.G. , Jung
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