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- SignalChem
- 加拿大
- P424-59-500
- 2025年07月13日
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- 技术资料
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
0.5 ml
存储溶液：Frozen substrate solution containing: 1mM of Phospha-tidylinositol 4,5-biphosphate [PI(4,5)P2 or PtdIns(4,5)P] in 1x Lipid Dilution Buffer (Catalog# L21-09).
官网链接：https://www.signalchem.com/product_details.php?id=13170
商品关键词：PI(4,5)P2,P424-59-500,SignalChem
简单描述：The substrate solution used for assaying lipid kinases.
Molecular Weight: The molecular weight of Phosphatidylinositol 4,5-bi-phosphate [PI(4,5)P2 or PtdIns(4,5)P] is: 856.48.
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文献和实验酶PTEN(phosphatase and tensin homolog deleted on chromosome ten)和SHIP(SH2-containing inositol 5-phosphatase)负调节, 他们分别从PIP3的3´和5´去除磷酸而将其转变成PI(4,5)P2和PI(3,4)P2而降解. 迄今为止, 尚未发现下调Akt活性的特异磷酸酶, 但用磷酸酶抑制剂处理细胞后, 发现Akt的磷酸化和活性均有所增加. 最近发现Akt能被一种C末端调节蛋白(CTMP)所失活, CTMP
Detection of Phosphatidylinositol-4-Phosphate 5-Kinase Activity Using Thin-Layer Chromatography
Phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks; EC 2.7.1.68) synthesize phosphatidylinositol 4,5-bisphosphate (PI 4,5-P2 ) from phosphatidylinositol 4-phosphate (PI 4-P). The hydrolysis of PI 4,5-P2 by phosphoinositide-specific
Phosphatidylinositol 4-Kinase Assay in Ovarian Carcinoma Cells
. Metabolic pathways including PI 4-kinase are now known as classical PI turnover pathways. PI-4-P formed with PI 4-kinase is then phosphorylated by PI-4-P kinase into PI-4,5-P2 . Phosphatidylinositol-specific phospholipase C(PI-PLC) is the rate-limiting
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