- ¥1380 - 2200
- LMAI Bio
- LM-8695R
- 进口/国产
- 2025年11月24日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-8695R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
PRMT2
- 抗体名：
蛋白精氨酸甲基转移酶2抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human PRMT2:81-160/433
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | PRMT2 |
| 中文名称 | 蛋白精氨酸甲基转移酶2抗体 |
| 别 名 | ANM2_HUMAN; EC 2.1.1.; histone arginine N methyltransferase PRMT2; Histone-arginine N-methyltransferase PRMT2; HMT 1; HMT1 (hnRNP methyltransferase S. cerevisiae) like 1; HMT1; HMT1 hnRNP methyltransferase like 1; hnRNP methyltransferase (S. cerevisiae) like 1; hnRNP methyltransferase like 1; Hrmt1l1; MGC111373; PRMT 2; PRMT2 alpha; prmt2; PRMT2 beta; PRMT2 gamma; PRMT2 protein; PRMT2L2; Protein arginine methyltransferase 2; Protein arginine N methyltransferase 2; Protein arginine N-methyltransferase 2; Zf2. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PRMT2:81-160/433 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | Function: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. Subunit: Self-associates. Interacts with RB1 and E2F1 (By similarity). Interacts with NCOA6 coactivator. Interacts (via SH3 domain) with PRMT8. Interacts with AR. Interacts with NFKBIA.Interacts with ESR1, ESR2, PGR, PPARG, RARA, RXRA and THRB.Interacts with HNRNPUL1. Subcellular Location: Cytoplasm. Nucleus. Translocates from the cytoplasm to the nucleus, after hormone exposure. Tissue Specificity: Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord. Similarity: Belongs to the protein arginine N-methyltransferase family. Contains 1 SH3 domain. SWISS: P55345 Gene ID: 3275 Database links: Entrez Gene: 3275 Human Entrez Gene: 15468 Mouse Entrez Gene: 499420 Rat Omim: 601961 Human SwissProt: P55345 Human SwissProt: Q9R144 Mouse Unigene: 154163 Human Unigene: 32020 Mouse Unigene: 145566 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: Brain (Mouse) Lysate at 40 ug Primary: Anti-PRMT2 (bs-8695R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 49 kD Observed band size: 49 kD  Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PRMT2) Polyclonal Antibody, Unconjugated (bs-8695R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. |
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文献和实验erasers 之间的平衡决定了哪些标记存在于组蛋白上，以及处于什么水平，最终控制特定的遗传程序及其编排的细胞 过程处于开启还是关闭状态。 表 1：组蛋白 writers 和 erasers 的主要类别。 修饰 Writers Erasers 乙酰化 组蛋白乙酰转移酶 (HATs) 组蛋白去乙酰化酶 (HDAC) 甲基化 组蛋白甲基转移酶（HMTs/KMTs）和蛋白精氨酸甲基转移酶 (PRMTs) 赖氨酸
【求助】P53的翻译后修饰都有哪些？ 怎样验证其修饰后与靶标启动子的结合活性的变化？
可通过p53结合蛋白PRMT1和CARM1（辅助活化因子相关的精氨酸甲基转移酶）相互作用获得。当靶基因的转录激活不再需要p53时去乙酰化作用可以作为一种快速的调节机制来抑制p53的功能。 泛素化修饰 正常细胞中降解是消除p53功能的唯一机制，这种降解部分是由泛素-26S蛋白酶体系统完成的（其它途径是非泛素依赖性的）。泛素是一种高度保守的蛋白质，靶向作用于底物蛋白，使其被26S蛋白酶体降解成多肽。泛素连接酶实现了泛素化修饰的最后一步，这些酶显示出一种高水平的靶向特异性。正常
，为了实现基因靶向转移，可以构建一种可溶性分子复合物载体系统，它包含两个功能区：DNA结合区，常用L―多聚赖氨酸、脂质体等，它们通过静电方式结合DNA或将DNA包裹；配体或抗体区，它们通过识别肿瘤细胞表面受体或抗原，选择性地内化进入肿瘤细胞。Uherek等将酵母转录因子Gal4的DNA结合结构域与白喉毒素转膜结构域、抗ErbB2抗体片段依次连接，构建了一种新的融合蛋白载体，它可与质粒形成复合物，用L―多聚赖氨酸处理后，可特异性地将外源基因导人ErbB2阳性的肿瘤细胞中。
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