DENTT细胞分裂核仁蛋白1抗体

DENTT细胞分裂核仁蛋白1抗体

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  • ¥1380 - 2200
  • LMAI Bio
  • LM-7051R
  • 进口/国产
  • 2025年12月12日
  • WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
  • Rabbit
  • Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 目录编号

      LM-7051R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      DENTT

    • 抗体名

      细胞分裂核仁蛋白1抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

    • 免疫原

      KLH conjugated synthetic peptide derived from human DENTT:251-350/693

    • 亚型

      IgG

    • 形态

      Lyophilized or Liquid

    • 应用范围

      WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)

    • 浓度

      1mg/ml

    • 保存条件

      Store at -20 °C

    • 规格

      100ul  200ul

    DENTT细胞分裂核仁蛋白1抗体
    英文名称 DENTT
    中文名称 细胞分裂核仁蛋白1抗体
    别    名 CASK interacting nucleosome assembly protein; CINAP; CDA1; Cell division autoantigen 1 nucleolar protein; CTCL tumor antigen se20-4; DENTT; Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa; TSPY-like 2; TSPY-like protein 2; Tspyl2; Testis-specific Y-encoded-like protein 2; Cutaneous T-cell lymphoma-associated antigen se20-4; SE20 4; SE204; CTCL-associated antigen se20-4; NP79; TSYL2_HUMAN.   
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 细胞生物  神经生物学  信号转导  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 76kDa
    细胞定位 细胞核 细胞浆 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human DENTT:251-350/693 
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    CASK interacting nucleosome assembly protein (CINAP) modulates gene expression and its abundance in cultured neurons is regulated by synaptic activity. CINAP is widely expressed in different regions of adult mouse brain, including the cerebral cortex, hippocampus, striatum, hypothalamus, cerebellum, and two adult brain regions known to generate progenitor neurons. During early development, CINAP is also expressed in regions where neuronal progenitor cells are actively dividing, the ventricular and subventricular zones, suggesting that in addition to regulating gene expression in mature neurons CINAP may also play a role in dividing cells.

    Function:
    Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.

    Subunit:
    Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2.

    Subcellular Location:
    Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons.

    Tissue Specificity:
    Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.

    Post-translational modifications:
    Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation (Probable).

    Similarity:
    Belongs to the nucleosome assembly protein (NAP) family.

    SWISS:
    Q9H2G4

    Gene ID:
    64061

    Database links:

    Entrez Gene: 64061 Human

    Entrez Gene: 52808 Mouse

    Entrez Gene: 302612 Rat

    Omim: 300564 Human

    SwissProt: Q9H2G4 Human

    SwissProt: Q7TQI8 Mouse

    Unigene: 136164 Human

    Unigene: 592916 Human

    Unigene: 9997 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

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