- ¥780 - 2200
- LMAI Bio
- LM-6724R
- 进口/国产
- 2026年01月06日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-6724R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
OTC
- 抗体名：
鸟氨酸氨基甲酰转移酶抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 免疫原：
KLH conjugated synthetic peptide derived from human OTC:51-150/354
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | OTC |
| 中文名称 | 鸟氨酸氨基甲酰转移酶抗体 |
| 别 名 | OCTD; Ornithine carbamoyltransferase mitochondrial; Ornithine Carbamoyltransferase; Ornithine carbamoyltransferase, mitochondrial; Ornithine transcarbamylase; Otc; OTC_HUMAN; OTCase. |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 细胞生物 信号转导 转录调节因子 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 细胞定位 | 细胞浆 线粒体 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OTC:51-150/354 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Defects in OTC are the cause of ornithine carbamoyltransferase deficiency (OTCD) [MIM:311250]. OTCD is an X-linked disorder of the urea cycle which causes a form of hyperammonemia. Mutations with no residual enzyme activity are always expressed in hemizygote males by a very severe neonatal hyperammonemic coma that generally proves to be fatal. Heterozygous females are either asymptomatic or express orotic aciduria spontaneously or after protein intake. The disorder is treatable with supplemental dietary arginine and low protein diet. The arbitrary classification of patients into the 'neonatal' group (clinical hyperammonemia in the first few days of life) and 'late' onset (clinical presentation after the neonatal period) has been used to differentiate severe from mild forms. Subunit: Homotrimer. Subcellular Location: Mitochondrion matrix. Tissue Specificity: Mainly expressed in liver and intestinal mucosa. Post-translational modifications: Acetylation at Lys-88 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. DISEASE: Defects in OTC are the cause of ornithine carbamoyltransferase deficiency (OTCD) [MIM:311250]. OTCD is an X-linked disorder of the urea cycle which causes a form of hyperammonemia. Mutations with no residual enzyme activity are always expressed in hemizygote males by a very severe neonatal hyperammonemic coma that generally proves to be fatal. Heterozygous females are either asymptomatic or express orotic aciduria spontaneously or after protein intake. The disorder is treatable with supplemental dietary arginine and low protein diet. The arbitrary classification of patients into the 'neonatal' group (clinical hyperammonemia in the first few days of life) and 'late' onset (clinical presentation after the neonatal period) has been used to differentiate severe from mild forms. Similarity: Belongs to the ATCase/OTCase family. SWISS: P00480 Gene ID: 5009 Database links: Entrez Gene: 5009 Human Entrez Gene: 18416 Mouse Entrez Gene: 25611 Rat Omim: 300461 Human SwissProt: P00480 Human SwissProt: P11725 Mouse SwissProt: P00481 Rat Unigene: 117050 Human Unigene: 2611 Mouse Unigene: 2391 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: HepG2 Cell (Human) Lysate at 40 ug Primary: Anti-OTC (bs-6724R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kD Observed band size: 45 kD |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Nat Immunol：华中科技大学黄波团队揭示记忆性 T 细胞通过氨解毒促进记忆形成的机制
步是转氨基作用介导的谷氨酸或谷氨酰胺的生成，第二步则是谷氨酸或谷氨酰胺的脱氨基作用生成。一般认为，氨在肝脏中通过尿素循环进行处理，肝细胞从外周循环中吸收氨，并使用氨基甲酰磷酸合成酶-1（CPS1）催化氨和碳酸氢盐（HCO3-），在线粒体中形成氨基甲酰磷酸（CP）。然后, CP 与鸟氨酸反应，通过鸟氨酸氨基甲酰磷酸转移酶（OTC）生成瓜氨酸。瓜氨酸之后进入胞浆，通过精氨酸琥珀酸合成酶 1（ASS1）与天冬氨酸结合生成精氨酸，然后精氨酸裂解酶（ASL）将其代谢为精氨酸和延胡索酸最终精氨酸酶 1（ARG
亦称鸟氨酸循环，是排尿素动物在肝脏中合成尿素的一个循环机制。肝细胞胞浆中的氨基酸经转氨作用与α -酮戊二酸形成的谷氨酸，透过线粒体膜进入线粒体基质，在谷氨酸脱氢酶作用下脱氨形成游离氨。形成的氨（ NH 4 ）与三羧酸循环产生的二氧化碳、 2分子 ATP，在氨基甲酰合成酶 I的催化下生成氨基甲酰磷酸。氨基甲酰磷酸在线粒体的鸟氨酸转氨基甲酰酶的催化下，将氨基甲酰基转移给鸟氨酸生成瓜氨酸。瓜氨酸形成后即离开线粒体进入胞浆，在 ATP的存在下，由精氨酸代琥珀酸合成酶的催化
3，同时也提供了该反应所需要的能量ATP。氨基甲酰磷酸合成酶I将有毒的氨转变成氨基甲酰磷酸，反应中生成的ADP又是谷氨酸脱氢酶的变构激活剂，促进谷氨酸进一步氧化脱氨。这种紧密偶联有利于迅速将氨固定在肝细胞线粒体内，防止氨逸出线粒体进入细胞浆，进而透过细胞膜进入血液，引起血氨升高。 2.瓜氨酸(citrulline)的生成： 乌氨酸氨基甲酰转移酶(ornithine transcarbamoylase)存在于线粒体中，通常与CPS－I形成酶的复合物催化氨基甲酰磷酸转甲酰基给鸟氨酸生成瓜氨酸
技术资料暂无技术资料 索取技术资料
