- ¥780 - 2200
- LMAI Bio
- LM-5792R
- 进口/国产
- 2026年03月26日
- WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-5792R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
MCPIP1
- 抗体名：
单核细胞趋化诱导蛋白1抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
- 免疫原：
KLH conjugated synthetic peptide derived from human MCPIP1:201-300/599
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | MCPIP1 |
| 中文名称 | 单核细胞趋化诱导蛋白1抗体 |
| 别 名 | dJ423B22.1; MCP 1 treatment-induced protein; MCP-induced protein 1; MCPIP 1; MCPIP; Ribonuclease ZC3H12A; RP3-423B22.1; ZC12A_HUMAN; ZC3H 12A; ZC3H12 A; Zc3h12a; Zinc finger CCCH domain-containing protein 12A; Zinc finger CCCH type containing 12A. |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 染色质和核信号 信号转导 细胞凋亡 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MCPIP1:201-300/599 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19. Function: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19. Subcellular Location: Cytoplasm. Nucleus. Similarity: Belongs to the ZC3H12 family. Contains 1 C3H1-type zinc finger. SWISS: Q5D1E8 Gene ID: 80149 Database links: Entrez Gene: 535344 Cow Entrez Gene: 80149 Human Entrez Gene: 230738 Mouse Omim: 610562 Human SwissProt: A6QQJ8 Cow SwissProt: Q5D1E8 Human SwissProt: Q5D1E7 Mouse Unigene: 656294 Human Unigene: 402 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: Raw264.7 Cell (Mouse) Lysate at 40 ug Hela Cell (Human) Lysate at 40 ug HepG2 Cell (Human) Lysate at 40 ug Primary: Anti- MCPIP1 (bs-5792R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 66 kD Observed band size: 66 kD  Blank control (Black line): HeLa (Black). Primary Antibody (green line): Rabbit MCPIP1 antibody (bs-5792R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Dilution: 3μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature.Acquisition of 20,000 events was performed.  k control (Black line): Hela (Black). Primary Antibody (green line): Rabbit Anti-MCPIP1 antibody (bs-5972R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-AF647 Dilution: 1μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at -20℃ .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed. |
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文献和实验趋化因子。这些细胞因子和趋化因子通过吸引CD4T细胞和单核细胞向损伤部位迁移、诱导MqD成熟和吸引更多的T细胞等方式增强炎症应答。角质形成细胞参与构成表皮结构的完整性，在表皮免疫学中发挥着重要作用。 身体中的很多部分都可发生Ⅳ型超敏反应。常见的有：出现特异性皮炎的皮肤、结核病患者的肺部、过敏性肺炎、Wegener肉芽肿、l型糖尿病(胰岛素依赖性糖尿病)的胰腺以及发生甲状腺炎症的甲状腺。
和黏附，参与了风湿性关节炎、肝炎、肺炎及移植耐受等过程。 2．CC型 又称臼趋化因子亚家族，结构特征为第1、第2半胱氨残基酸紧密相连。该亚家族的基因大多数位于入染色：体17qll―32或小鼠第11号染色体，含有2个内含子和3个外显子。CC趋化因子主要作用于单核细胞和淋巴细胞，这和CXC型亚家族成员主要作用于中性粒细胞不同。CC趋化因子还促进其他类型细胞的游走趋化，如淋巴细胞、DC、NK细胞、嗜酸粒细胞、嗜碱粒细胞等。该亚家族的代表成员是单核细胞趋化蛋白(MCP-1，)，功能是使单核细胞离开
-1)及其受体CXCR5基因敲除鼠证实，这些趋化因子对脾脏初级滤泡结构的正确形成至关重要。 2．诱导性表达的趋化因子 可诱导性的趋化因子一般发现得较早，因为在相应组织中的表达水平高。如MIP―1α／CCL3、MIP―lβ／CCL4以及单核细胞趋化蛋白1(MCP―1／CCL2)最初即由I。PS刺激的Mφ中分离，干扰素诱导蛋白(1P―10／CXCLl0)和IL8则来自活化的单核细胞。诱导性趋化因子皆属CC型和CXC型．拥有高度保守的半胱氨酸基序(4个半胱氨酸构成两个二硫键)。再加上活化T
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