Amylin (8-37), rat,138398-61-5

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Amylin (8-37), rat

CAS No. : 138398-61-5

MCE 国际站：Amylin (8-37), rat

产品活性：Amylin (8-37), rat 是天然胰淀素的一种截短肽段，其选择性抑制肌肉组织中胰岛素相关的葡萄糖摄取和糖原沉积。Amylin (8-37), rat 是一种稍弱的胰淀素受体 (amylin receptor, AMY) 拮抗剂。

研究领域：Others

作用靶点：Others

In Vitro: Amylin (8-37), rat (Rat amylin-(8-37)) enhances insulin action and alters lipid metabolism in normal and insulin-resistant rats. Amylin (8-37) reduces plasma insulin (P<0.001) and enhances several measures of whole body and muscle insulin sensitivity (P<0.05) in both saline- and hGH-infused rats. Amylin-(8-37) corrects hGH-induced liver insulin resistance, increases basal plasma triglycerides and lowers plasma nonesterified fatty acids in both groups, and reduces muscle triglyceride and total long-chain acyl-CoA content in saline-treated rats (P<0.05). In isolated soleus muscle, Amylin (8-37) blocks amylin-induced inhibition of glycogen synthesis but has no effect in the absence of amylin. Thus 1) hyperamylinemia accompanies insulin resistance induced by hGH infusion; 2) Amylin (8-37) increases whole body and muscle insulin sensitivity and consistently reduces basal insulin levels in normal and hGH-induced insulin resistant rats; and 3) Amylin (8-37) elicits a significant alteration of in vivo lipid metabolism.

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