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Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
- CAS号：
72814-32-5
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2432.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1400.0 |
| 规格： | 5 mg | 产品价格： | ￥3000.0 |
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BW 245C
CAS No. : 72814-32-5
MCE 国际站：BW 245C
产品活性：BW 245C 是一种有效的前列腺素类DP受体prostanoid DP-receptor (DP1)激动剂，常用于中风等疾病的研究。
研究领域：GPCR/G Protein
作用靶点：Prostaglandin Receptor
In Vitro: BW245C (0.01-1 μM) suppresses TGF-β-induced collagen secretion in a dose-dependent manner in Th2 cells. BW245C (0.01-1 μM) also increases intracellular cAMP in lung fibroblasts. BW245C (0.1-3 μmol/L) dose-dependently increases transendothelial electrical resistance and decreases the FITC-dextran permeability of human umbilical vein endothelial cells. BW245C (0.3 μmol/L) increases the intracellular cAMP level and subsequent protein kinase A (PKA) activity.
In Vivo: BW245C (0.02, 0.2, and 2.0 mg/kg) in WT mice results in a significant increase in CBF, but this effect of this treatment is absent in DP1?/? mice. BW245C attenuates functional deficits after stroke. BW245C significantly reverses these conditions that neurologic deficit is significantly augmented, whereas locomotor activity is significantly reduced after stroke in WT mice. BW245C (0.2 mg/kg) injection 1 h after stroke results in a significant decrease in brain infarction in WT mice, whereas the effect of this treatment is not observed in DP1?/? mice. BW245C improves CBF during and after stroke. BW245C results in significantly prolonged bleeding compared with the vehicle-treated group. BW 245C (100 nM) does not significantly increase MBP-positive eosinophils in esophageal epithelium in OVA-sensitized guinea pigs.
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文献和实验A, Aichinger M, et al. Generation of blood vessel organoids from human pluripotent stem cells[J]. Nature protocols, 2019, 14(11): 3082-3100. 【4】Sommer C J. Ischemic stroke: experimental models and reality[J]. Acta neuropathologica, 2017, 133(2): 245-261. 【5】Lu
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