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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
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5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 5 mg | 产品价格： | ￥565.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥880.0 |
| 规格： | 25 mg | 产品价格： | ￥1660.0 |
| 规格： | 50 mg | 产品价格： | ￥2650.0 |
| 规格： | 100 mg | 产品价格： | ￥3936.0 |
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AMG-208
CAS No. : 1002304-34-8
MCE 国际站：AMG-208
产品活性：AMG-208 是一种口服有效的，选择性 c-Met/RON 双抑制剂，对 c-Met 的 IC50 为 9 nM。AMG-208 是一种 CYP3A4 抑制剂，IC50 为 32 μM。AMG-208 具有抗癌活性。
研究领域：Protein Tyrosine Kinase/RTK | Metabolic Enzyme/Protease
作用靶点：c-Met/HGFR | Cytochrome P450
In Vitro: AMG-208 (compound 4) treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM.
Pre-incubation of AMG-208 (compound 1) with human liver microsomes for 30 minutes shows a potent time-dependent inhibition for CYP3A4 metabolic activity with IC50 of 4.1 μM, which is an eightfold decrease relative to the IC50 (32 μM) without preincubation.
In Vivo: In male Sprague Dawley rats, AMG-208 (0.5 mg/kg i.v.) shows a high bioavailability with Cl of 0.37 L/h/kg, Vss of 0.38 L/kg and T1/2 of 1 hour.
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文献和实验freedegree hsa-miR-625 和hsa-miR-625* hsa-mir-532-5p 和hsa-miR-532-3p hsa-mir-34a 和 hsa-mir-34b （同源？？） hsa-let-7a-2 和 hsa-let-7a-1 （分布不同？？） 晕了，赐教啊 zhujoker hsa-miR-625 和hsa-miR-625* 这2个第一个
【资源】Electrophoresis in Practice 4th edition
in restrictive gels 21 1.2.1 The Ferguson plot 21 1.2.2 Agarose gel electrophoresis 22 1.2.3 Polyacrylamide gel electrophoresis of nucleic acids 24 1.2.4 Polyacrylamide gel electrophoresis of proteins 34 2 Isotachophoresis 45 2.1 Migration
（berkelium） Bk 97 (247) 铍（beryllium） Be 4 9.01 铋（bismuth） Bi 83 208.98
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