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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
RO5045337
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
939981-39-2
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1761.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥500.0 |
| 规格： | 5 mg | 产品价格： | ￥1100.0 |
| 规格： | 10 mg | 产品价格： | ￥1900.0 |
| 规格： | 25 mg | 产品价格： | ￥3800.0 |
| 规格： | 50 mg | 产品价格： | ￥5700.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
RG7112
CAS No. : 939981-39-2
MCE 国际站：RG7112
产品活性：RG7112 是有效的、选择性的、第一个用于临床的、可口服的、可透过血脑屏障的、 MDM2-p53 抑制剂，IC50 值为 18 nM，结合到MDM2 的KD 值为 11 nM.
研究领域：Apoptosis | Metabolic Enzyme/Protease
作用靶点：MDM-2/p53 | E1/E2/E3 Enzyme
In Vitro: RG7112 (0-5 μM) stabilizes wild-type p53 and induces p53 signaling in cancer cells. RG7112 effectively activates p53 functions in cancer cells.
In Vivo: RG7112 (25-200 mg/kg, single oral dose) activates p53 pathway and induces apoptosis in tumor cells in vivo.
?RG7112 (100 mg/kg, gavage once per day, 5 days/week for 3 weeks ) reduces tumor growth rate and increases survival in GBM models.
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