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- 2025年12月05日
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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg/200 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥825.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥234.0 |
| 规格： | 5 mg | 产品价格： | ￥468.0 |
| 规格： | 10 mg | 产品价格： | ￥750.0 |
| 规格： | 50 mg | 产品价格： | ￥2200.0 |
| 规格： | 100 mg | 产品价格： | ￥3500.0 |
| 规格： | 200 mg | 产品价格： | ￥5413.0 |
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GW2580
CAS No. : 870483-87-7
MCE 国际站：GW2580
产品活性：GW2580 是口服有效的，选择性的 c-Fms 激酶抑制剂，体外实验中在 0.06 μM 时可完全抑制人 cFMS 激酶。GW2580 是 ATP 与 cFMS 激酶结合的竞争性抑制剂，并且可以抑制集落刺激因子 1 信号传导。
研究领域：Protein Tyrosine Kinase/RTK
作用靶点：c-Fms
In Vitro: GW2580 completely inhibits the growth of CSF-1-dependent mouse myeloid M-NFS-60 cells at 0.7 μM. GW2580 at 0.8-1 μM completely blocks the ability of CSF-1 to induce the growth of mouse M-NFS60 myeloid cells and human monocytes.
GW2580 causes a 30-40% inhibition of PTH-induced calcium release at 0.1-0.3 μM, with higher concentrations of 1, 3, and 10 μM completely inhibiting the PTH response.
GW2580 inhibits CSF1R phosphorylation in RAW264.7 murine macrophages stimulated with 10 ng/mL with IC50 of approximately 10 nM.
GW2580 also inhibits TRKA activity with IC50 of 0.88 μM.
In Vivo: GW2580 (Oral administration; 20 and 80 mg/kg) produces a dose-related decrease in the number of tumor cells, with the 80 mg/kg dose completely blocking tumor growth.
GW2580 (Oral administration; 20 and 80 mg/kg) has gave maximal plasma concentrations of 1.4 and 5.6 μM, respectively.
GW2580 (50 mg/kg; twice a day from days 0 to 21, 7 to 21, or 14 to 21) inhibits joint connective tissue and bone destruction in a 21-day adjuvant arthritis model.
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文献和实验9sMffkekXB4sNHvv7vvutpeWLrO//NLf2GOPL5F98YAbNRHkguTs7e23I6bPsgkHTbOZM2farKOOs23btslRRdkee2yJPfHkr23lyhX21f/2d3bHojvsTm3HHnu0Pf/i87ZixTIn8GulAb/yBz+0Y2bMsqt+8H2787bb7KQTZ9vqlSvtWRH6937g/Xb9gpusX2YhW3butKuvv86+8BeftZdfftlOPflke2HpUmnAV9nalWttZ1ePzEiY7eccWX+hKVB
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only, during lactation only, or during gestation and lactation (stopping at weaning of offspring), or can continue past weaning at postnatal day (PND) 21 and through adulthood to encompass earlier measurements in the offspring. GD = gestation day, GW = gestation week
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