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KRCA-0008
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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
货期:1-2天
MedChemExpress LLC
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
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CAS No. : 1472795-20-2
MCE 国际站:KRCA-0008
产品活性:KRCA-0008 是选择性的 ALK/Ack1 抑制剂,对 ALK 和 Ack1 的 IC50 值分别为 12 和 4 nM。KRCA-0008 可用于癌症的研究。
研究领域:Protein Tyrosine Kinase/RTK | Apoptosis
作用靶点:Ack1 | Anaplastic lymphoma kinase (ALK) | Apoptosis
In Vitro: KRCA-0008 (0-1000 μM) shows potency to ALK (wt), ALK L1196 M, ALK C1156Y, ALK F1174L, ALK R1275Q and insulin receptor with IC50s of 12, 75, 4, 17, 17 and 210 nM, respectively.?KRCA-0008 (0-1000 nM; 4 h) inhibits ALK-dependent signaling pathways more potently than crizotinib.?KRCA-0008 (0-1000 nM; 72 h) induces cell apoptosis.?KRCA-0008 (0-100 nM; 48 h) affects cell cycle.
In Vivo: KRCA-0008 (25 and 50 mg/kg; p.o. twice a day for two weeks) suppresses tumor growth in an ALK-positive Karpas-299 xenograft model.
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