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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
331771-20-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥452.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥200.0 |
| 规格： | 5 mg | 产品价格： | ￥400.0 |
| 规格： | 10 mg | 产品价格： | ￥700.0 |
| 规格： | 25 mg | 产品价格： | ￥1540.0 |
| 规格： | 50 mg | 产品价格： | ￥2600.0 |
| 规格： | 100 mg | 产品价格： | ￥4500.0 |
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ZM-447439
CAS No. : 331771-20-1
MCE 国际站：ZM-447439
产品活性：ZM-447439是极光激酶 (aurora) 抑制剂，对aurora A和B的 IC50 值分别为110和130 nM。
研究领域：Cell Cycle/DNA Damage | Epigenetics | Apoptosis
作用靶点：Aurora Kinase | Apoptosis
In Vitro: Cells treated with ZM-447439 progress through interphase, enter mitosis normally, and assemble bipolar spindles. However, chromosome alignment, segregation, and cytokinesis all fail. ZM-447439 inhibits cell division and inhibit mitotic phosphorylation of histone H3. ZM-447439 prevents chromosome alignment and segregation. ZM-447439 compromises spindle checkpoint function. ZM-447439 inhibits kinetochore localization of BubR1, Mad2, and Cenp-E. Inhibition of Aurora kinase by ZM-447439 reduces histone H3 phosphorylation at Ser10 in Hep2 carcinoma cells. Multipolar spindles are induced in these ZM-treated G2/M-arrested cells with accumulation of 4N/8N DNA, similar to cells with genetically suppressed Aurora-B. ZM-447439 treatment induces cell apoptosis. ZM-447439 inhibition of Aurora kinase is potently in association with decrease of Akt phosphorylation at Ser473 and its substrates GSK3α/β phosphorylation at Ser21 and Ser9.
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文献和实验The Ipl1/Aurora Kinase Family: Methods of Inhibition and Functional Analysis in Mammalian Cells
-molecule inhibitor ZM447439, RNA interference, and overexpression of a catalytic mutant. All of these methods have proved useful in studying Aurora B as well as validating it as a potential anticancer drug target. However, while all three methods are useful
ZOOM® IPGRunner™系统：简化的双向电泳（2D gel eletrophoresis）
Staining Kit 或者SimplyBlue™ SafeStain染色 90或者45分钟 方法 第一向 IEF 在ZOOM® IPG RunnerTM夹盒(Invitrogen, Cat. no. ZM0003)中再水化ZOOM®胶条，pH4-7（Invitrogen, Cat. no. ZM0012）。IPG
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