- ¥1380 - 2200
- LMAI Bio
- LM-5021R
- 进口/国产
- 2025年12月19日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Pig, Rabbit, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-5021R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
ACOX1
- 抗体名：
过氧化物酶酰基辅酶A氧化酶1抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Pig, Rabbit, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human ACOX1:221-320/660
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | ACOX1 |
| 中文名称 | 过氧化物酶酰基辅酶A氧化酶1抗体 |
| 别 名 | ACOX1; ACOX1_HUMAN; AOX antibody Palmitoyl CoA oxidase; Palmitoyl-CoA oxidase; Peroxisomal acyl coenzyme A oxidase 1; Peroxisomal acyl-coenzyme A oxidase 1; SCOX; Straight chain acyl CoA oxidase; Straight-chain acyl-CoA oxidase. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Rabbit, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 74kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ACOX1:221-320/660 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Defects in ACOX1 are the cause of adrenoleukodystrophy pseudoneonatal (Pseudo-NALD); also known as peroxisomal acyl-CoA oxidase deficiency. Pseudo-NALD is a peroxisomal single-enzyme disorder. Clinical features include mental retardation, leukodystrophy, seizures, mild hepatomegaly, hearing deficit. Pseudo-NALD is characterized by increased plasma levels of very-long chain fatty cids, due to decreased or absent peroxisome acyl-CoA oxidase activity. Peroxisomes are intact and functioning. Function: Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA. Subcellular Location: Peroxisome. Tissue Specificity: Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart. DISEASE: Defects in ACOX1 are the cause of adrenoleukodystrophy pseudoneonatal (Pseudo-NALD) [MIM:264470]; also known as peroxisomal acyl-CoA oxidase deficiency. Pseudo-NALD is a peroxisomal single-enzyme disorder. Clinical features include mental retardation, leukodystrophy, seizures, mild hepatomegaly, hearing deficit. Pseudo-NALD is characterized by increased plasma levels of very-long chain fatty cids, due to decreased or absent peroxisome acyl-CoA oxidase activity. Peroxisomes are intact and functioning. Similarity: Belongs to the acyl-CoA oxidase family. SWISS: Q15067 Gene ID: 51 Database links: Entrez Gene: 51 Human Entrez Gene: 11430 Mouse Entrez Gene: 50681 Rat Omim: 609751 Human SwissProt: Q15067 Human SwissProt: Q9R0H0 Mouse SwissProt: P07872 Rat Unigene: 464137 Human Unigene: 356689 Mouse Unigene: 31796 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验过氧化物酶体中的主要酶类, 氧化酶约占过氧化物酶体酶总量的一半, 包括：尿酸氧化酶、D-氨基酸氧化酶、L-氨基酸氧化酶和L-α-羟基酸氧化酶等。各种氧化酶作用于不同的底物,其共同特征是氧化底物的同时,将氧还原成过氧化氢。
过氧化物酶体是由一层单位膜包裹的囊泡, 直径约为0.5～1.0μm, 通常比线粒体小。与溶酶体不同,过氧化物酶体不是来自内质网和高尔基体,因此它不属于内膜系统的膜结合细胞器。过氧化物酶体普遍存在于真核生物的各类细胞中,但在肝细胞和肾细胞中数量特别多。过氧化物酶体的标志酶是过氧化氢酶,它的作用主要是将过氧化氢水解。H2O2是氧化酶催化的氧化还原反应中产生的细胞毒性物质,氧化酶和过氧化氢酶都存在于过氧化物酶体中,从而对细胞起保护作用。过氧化物酶体在1954年被发现时, 由于不知道这种
由于抗M1抗体即抗心磷脂抗体，目前不列入抗线粒抗体中。抗M2见于90%的PBC患者，常用作该病的重要实验室诊断指标，但AMA与PBC的病期、疾病严重程度、治疗效果均无相关性。除PBC外，抗M2也见于慢性活动性肝炎（CAH）、HBsAg阴性的肝病。抗M3AMA见于吡唑酮（pyrazolone）系列药物诱发的假红斑狼疮（PLE）综合征患者；抗M4AMA也见于PBC；抗M9见于PBC早期；抗M5见于SLE、自身免疫性溶血性贫血；抗M6见于异丙烟肼（iproniazid，一种单胺氧化酶
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