- ￥1419
- abgent
- AD80276
- 美国
- 2025年07月21日
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- 详细信息
- 技术资料
- 供应商：
上海研卉生物科技有限公司
- 库存：
现货
- 抗体英文名：
b-FGF Antibody Mouse Monoclonal
- 规格：
6ml
碱性成纤维生长因子bFGF免疫组化抗体，Mouse Monoclonal
b-FGF Antibody Mouse Monoclonal
b-FGF Antibody Mouse Monoclonal
Application
|
IHC |
|---|---|
| Primary Accession | P09038 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 223A7B2 |
| Gene ID | 2247 |
|---|---|
| Gene Name | FGF2 |
| Other Names | Fibroblast growth factor 2, FGF-2, Basic fibroblast growth factor, bFGF, Heparin-binding growth factor 2, HBGF-2, FGF2, FGFB |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | b-FGF Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Synonyms | FGFB |
|---|---|
| Function | Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). |
| Cellular Location | Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 |
| Tissue Location | Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. |
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碱性成纤维生长因子bFGF免疫组化抗体，Mouse Monoclonal
￥1419
