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KCNH1钾离子通道蛋白EAG1抗体

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  • ¥1380 - 2200
  • LMAI Bio
  • LM-2424R
  • 进口/国产
  • 2025年07月11日
  • WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）
  • Rabbit
  • Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
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上海联迈生物工程有限公司
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 供应商：

      上海联迈生物工程有限公司

    • 库存：

      大量

    • 目录编号：

      LM-2424R

    • 克隆性：

      多克隆

    • 抗原来源：

      Rabbit

    • 保质期：

      1年

    • 抗体英文名：

      KCNH1

    • 抗体名：

      钾离子通道蛋白EAG1抗体

    • 宿主：

      Rabbit

    • 适应物种：

      Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

    • 免疫原：

      KLH conjugated synthetic peptide derived from human KCNH1:501-600/989 <Cytoplasmic>

    • 亚型：

      IgG

    • 形态：

      Lyophilized or Liquid

    • 应用范围：

      WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）

    • 浓度：

      1mg/ml

    • 保存条件：

      Store at -20 °C

    • 规格：

      100ul  200ul

    KCNH1钾离子通道蛋白EAG1抗体
    英文名称 KCNH1
    中文名称 钾离子通道蛋白EAG1抗体
    别    名 EAG1; EAG 1; EAG-1; KCNH 1; KCNH-1; h eag; Kv10.1; MGC124420; MGC142269; EAG; Ether a go go potassium channel 1; hEAG1; M eag; MGC124419; Potassium voltage gated channel subfamily H (eag related), member 1; Voltage gated potassium channel subunit Kv10.1; KCNH1_HUMAN.  
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 肿瘤  细胞周期蛋白  通道蛋白  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复） 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 111kDa
    细胞定位 细胞膜 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human KCNH1:501-600/989 <Cytoplasmic>
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].

    Function:
    Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts.

    Subunit:
    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2. Interacts with ALG10B (By similarity).

    Subcellular Location:
    Membrane; Multi-pass membrane protein.

    Tissue Specificity:
    Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.

    Similarity:
    Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily.
    Contains 1 cyclic nucleotide-binding domain.
    Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.

    SWISS:
    O95259

    Gene ID:
    3756

    Database links:

    Entrez Gene: 3756 Human

    Entrez Gene: 16510 Mouse

    Entrez Gene: 65198 Rat

    Omim: 603305 Human

    SwissProt: O95259 Human

    SwissProt: Q60603 Mouse

    SwissProt: Q63472 Rat

    Unigene: 553187 Human

    Unigene: 4489 Mouse

    Unigene: 11071 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

    KCNH1钾通道蛋白在调控细胞增殖和细胞周期进程中起重要作用。Eag1是膜蛋白, 参与细胞信号转导, 在正常组织和恶性肿瘤中有独特的表达特点.
    一些离子通道如钾、钙、氯、钠等通道与肿瘤相关，特别是钾通道与肿瘤的关系最为密切。钾通道是细胞膜上种类最多、最为复杂的一类离子通道，它存在于多种细胞中，是细胞膜电位的重要控制因素。
    产品图片 产品细节图片1
    Sample: 
    Hippocampus (Mouse) Lysate at 40 ug
    Primary: Anti- KCNH1 (bs-2424R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 111 kD
    Observed band size: 111 kD

    产品细节图片2
    Blank control: Hela(blue). 
    Primary Antibody:Rabbit Anti-KCNH1 antibody(bs-2424R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; 
    Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); 
    Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
    Protocol
    The cells were fixed with 2% paraformaldehyde (10 min). Antibody (bs-2442R, 1μg /1x10^6 cells) were incubated for 30 min on the ice, followed by 1 X PBS containing 0.5% BSA + 10% goat serum (15 min) to block non-specific protein-protein interactions. Then the Goat Anti-rabbit IgG/PE antibody was added into the blocking buffer mentioned above to react with the primary antibody of bs-2442R at 1/200 dilution for 30 min on ice. Acquisition of 20,000 events was performed.

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    图标文献和实验
    相关实验

    • 酵母细胞的异源功能互补

      与鉴定的植物基因的例子很多，其中有Fe（Ⅱ）转运蛋白基因IRTⅠ、Fe（Ⅲ）螯合物还原酶基因FRO2，拟南芥菜的NH4-transporter，西红柿中两个铁调控的离子转运蛋白cDNAs（LeIRT1,LeIRT2），玉米YS1（yellow stripel）基因以及大麦SFD1等。另外在研究钾离子通道蛋白方面结合定点诱变、随机诱变等对通道蛋白的结构及功能可作出很好的遗传分析。 三、实验原理 　　缺铁胁迫时，酵母主要通过高亲和系统来转运铁离子，有如下几个步骤：①转录

    • 自身抗体检测在自身免疫病中的临床应用专家建议

      。 2.3.2 抗水通道蛋白 4(AQP4)抗体：是视神经脊髓炎 (NMO) 的标志性抗体。可用于 NMO 与多发性硬化的鉴别，在 NMO 患者中的敏感性约为 58%—76%，特异性可达 85%-99%。IIF 或基于靶抗原转染细胞的检测 (CBA) 是首选检测方法。 2.3.3 其他中枢神经系统疾病相关的自身抗体：抗神经节苷脂抗体与吉兰．巴雷综合征 (Guillain Barre syndrome)、多灶性运动神经病、感觉神经病、米．费综合征(Miller-Fisher syndrome

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