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- 中国
- 核受体筛选模型
- 2026年04月24日
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- 详细信息
- 文献和实验
- 技术资料
- 服务名称：
药物活性筛选服务
- 提供商：
武汉合研生物医药科技有限公司
武汉合研生物医药科技有限公司坐落于光谷生物城，是一家专注于提供新药发现阶段的技术服务，以中小微新药研发企业为服务主体的创新型公司。合研生物拥有一支训练有素的药物研发技术团队，提供的服务覆盖虚拟筛选、酶学靶点筛选、抗肿瘤药物活性评价、细胞功能学检测、药理病理学服务等各项技术。我们的技术团队在分子生物学、细胞生物学、结构生物学等领域具有丰富的经验，通过酶水平、细胞水平测定等技术平台帮助客户进行化合物筛选及化合物特性、作用机制等研究。合研生物以高效、高性价比的专业服务帮助客户更快地达到目标，帮助客户推进药物发现的进程。
我们的优势
合研生物拥有丰富的核受体筛选经验，可提供96孔板型的筛选模式，加速您的药物研发进程。
| Target | Assay | Format |
| ER alpha | Cell based | 96 |
| ER beta | Cell based | 96 |
| glucocorticoid receptor (GR) | Cell based | 96 |
| LXR (liver X receptor) beta | Cell based | 96 |
| Androgen Receptor | Cell based | 96 |
| Constitutive Androstane Receptor (CAR) | Cell based | 96 |
| ERR (estrogen related receptor) alpha | Cell based | 96 |
| ERR (estrogen related receptor) beta | Cell based | 96 |
| Estrogen Related Receptor (ERR) gamma | Cell based | 96 |
| FXR (farnesoid X receptor) | Cell based | 96 |
| LXR (liver X receptor) alpha | Cell based | 96 |
| PPAR alpha | Cell based | 96 |
| PPAR delta | Cell based | 96 |
| PPAR gamma | Cell based | 96 |
| Progesterone Receptor | Cell based | 96 |
| PXR (SXR) | Cell based | 96 |
| RAR (retinoic acid receptor) beta | Cell based | 96 |
| Retinoic Acid Receptor (RAR) alpha | Cell based | 96 |
| Retinoic Acid Receptor (RAR) gamma | Cell based | 96 |
| Retinoid X Receptor (RXR) beta | Cell based | 96 |
| TR (thyroid receptor) alpha | Cell based | 96 |
| TR (thyroid receptor) beta | Cell based | 96 |
| TR-FRET LXR (liver X receptor) beta | Cell based | 96 |
| Vitamin D Receptor (VDR) | Cell based | 96 |
| mineralocorticoid receptor(MR) | Cell based | 96 |
| Retinoid X Receptor (RXR) alpha | Cell based | 96 |
| Retinoid X Receptor (RXR) gamma | Cell based | 96 |
| constitutive androstane receptor isoform 1 | Cell based | 96 |
| constitutive androstane receptor isoform 3 | Cell based | 96 |
| RAR-related orphan receptor gamma (RORγ) | Cell based | 96 |
| Aryl Hydrocarbon Receptor | Cell based | 96 |
| Pregnane X Receptor | Cell based | 96 |
| Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) | Cell based | 96 |
| Liver Receptor Homolog-1 | Cell based | 96 |
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文献和实验Human peptide Orphan receptor Ligand source 1995 Nociceptin/Orphanin FQ
Overview of Receptor Allosterism
change in the GPCR that can alter orthosteric ligand affinity and/or efficacy. Moreover, there has been an increase in recent years in the identification of allosteric agonists that can directly activate the receptor in the absence of orthosteric ligand
Isolation of NK Cells and NK-Like Cells from the Intestinal Lamina Propria
did not receive much attention. Recently, data have become available identifying two distinct subsets of mucosal NKp46+ lymphocytes based on the expression of the orphan transcription factor RORγt. In many ways, the RORγt− subset resembled “classical” NK cells
