SLC19A3 antibody

SLC19A3 antibody

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  • ¥1380 - 2200
  • 康朗生物
  • kl-8702R
  • 中国/美国/德国
  • 2025年11月13日
  • WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
  • Rabbit
  • Human, Mouse, Rat,
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    • 详细信息
    • 技术资料
    • 供应商

      上海康朗生物科技有限公司

    • 库存

      大量

    • 目录编号

      kl-8702R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      12个月

    • 抗体英文名

      SLC19A3 antibody

    • 抗体名

      溶质载体家族19成员3抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Mouse, Rat,

    • 免疫原

      KLH conjugated synthetic peptide derived from human SLC19A3:261-360/496 <Extracellular>

    • 亚型

      IgG

    • 形态

      冻干粉或液体

    • 应用范围

      WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500

    • 浓度

      1mg/ml

    • 保存条件

      -20 °C

    • 规格

      100ul 200ul

    SLC19A3 antibody
    中文名称 溶质载体家族19成员3抗体
    别    名 Solute carrier family 19 member 3; Thiamine transporter 2; thTr 2; THTR2.  
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 细胞生物  神经生物学  信号转导  转运蛋白  跨膜蛋白  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 56kDa
    细胞定位 细胞膜 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human SLC19A3:261-360/496 <Extracellular>
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild mental retardation, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.[provided by RefSeq, Jan 2010]

    Function:
    Mediates high affinity thiamine uptake, propably via a proton anti-port mechanism. Has no folate transport activity.

    Subcellular Location:
    Plasma membrane.

    Tissue Specificity:
    Widely expressed but most abundant in placenta, kidney and liver. 

    DISEASE:
    The disease is caused by mutations affecting the gene represented in this entry. 
    Disease description:An autosomal recessive metabolic disorder characterized by episodic encephalopathy, often triggered by febrile illness, presenting as confusion, seizures, external ophthalmoplegia, dysphagia, and sometimes coma and death. If untreated, encephalopathies can result in permanent dystonia. Brain imaging may show characteristic bilateral lesions of the basal ganglia.

    Similarity:
    Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. 

    SWISS:
    Q9BZV2

    Gene ID:
    80704

    Database links:

    Entrez Gene: 80704 Human

    Omim: 606152 Human

    SwissProt: Q9BZV2 Human

    Unigene: 221597 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
     
    产品图片 SLC19A3 antibody
    Sample: 
    Liver (Mouse) Lysate at 40 ug
    Primary: Anti-SLC19A3 (bs-8702R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 56 kD
    Observed band size: 56 kD

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