- ¥1380 - 2200
- LMAI Bio
- LM-1484R
- 进口/国产
- 2025年07月10日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-1484R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
MTHFR
- 抗体名：
亚甲基四氢叶酸还原酶MTHFR抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 免疫原：
KLH conjugated synthetic peptide derived from human MTHFR:165-300/656
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | MTHFR |
| 中文名称 | 亚甲基四氢叶酸还原酶MTHFR抗体 |
| 别 名 | 5 10 methylenetetrahydrofolate reductase (NADPH); 5 10 methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase intermediate form; MTHR_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 75kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MTHFR:165-300/656 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to neural tube defects, occlusive vascular disease, colon cancer and acute leukemia. Mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency. Function: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Subunit: Homodimer. DISEASE: Methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]: Autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders. Note=The disease is caused by mutations affecting the gene represented in this entry. Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Folate-sensitive neural tube defects (FS-NTD) [MIM:601634]: The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Similarity: Belongs to the methylenetetrahydrofolate reductase family. SWISS: P42898 Gene ID: 4524 Database links: Entrez Gene: 4524 Human Entrez Gene: 17769 Mouse Entrez Gene: 362657 Rat Omim: 607093 Human SwissProt: P42898 Human SwissProt: Q9WU20 Mouse Unigene: 214142 Human Unigene: 89959 Mouse Unigene: 10494 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)是叶酸代谢的关键酶,为细胞内的各种甲基化反应提供甲基基团,在DNA甲基化中起重要作用。 |
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文献和实验或转硫作用的酶缺陷所致，常见的有胱硫酶合成酶及亚甲基四氢叶酸还原酶缺陷，极度同型半胱氨酸血症病人有早发性动脉粥样硬化，动静脉栓塞及智力障碍。 近年来，人们开始注意同型半胱氨酸与心血管疾病的联系。大量的事实表明轻微到中度同型半胱氨酸血症（tHCY浓度≥12umol/L，但≤100umol/L）是动脉粥样硬化所致心血管疾病最广泛、最强的独立的致病因素。1997年人群调查表明，人群tHCY浓度偏高的地区，心血管疾病所致的死亡率增加。1998年对血浆tHCY浓度不同
，也可每2～4月给予1mg，但以每月给予一次维持量复发机会少。有神经系统症状者维生素B12剂量应稍大，且维持治疗宜2周一次，凡神经系统症状持续超过1年者难以恢复。凡恶性贫血、胃切除者、Imerslund综合征及先天性内因子缺陷者需终身维持治疗。维生素B12缺乏单用叶酸治疗是禁忌的，因会加重神经系统的损害。叶酸缺乏者可口服叶酸，每日3次，每次5mg，对肠道吸收不良者也可肌内注射甲酰四氢叶酸钙3～6mg/D，直至贫血和病因被纠正。如不能明确是哪一种缺乏，也可以维生素B12和叶酸联合应用。也有认为对营养性巨幼
化酶的催化下可使脂性过氧化物还原，从而消除其对组织细胞的破坏作用，而G－SH便氧化成G－S－S－G，在谷胱甘肽还原酶催化下，维生素C也可使G－S－S－G还原成G－SH，从而使后者不断得到补充。 图3-6 维生素C与谷胱甘肽拉化还原反应的关系 (1)：G-SH还原酶(2)：G-SH过氧化酶 再如某些含巯基的酶在金属中毒(如铅中毒)时被抑制，给以大量维生素C往往可以缓解其毒性。据认为，金属离子能与体内巯基酶类的�H结合，使其失活，以致代谢障碍而中毒。维生素C可以将G－S－S
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