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- Peprotech
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- 2025年12月10日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 供应商：
嵘崴达
- 库存：
需确认
- 英文名：
Recombinant Human MMP-2
- 规格：
2ug
产品描述
Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-2 is a secreted collagenase with specificity toward Type IV, V, VII, and X collagens. Recombinant Human MMP-2 is a 62.0 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (552 amino acids).
Source:E.coli
Synonyms:Matrix Metalloproteinase-2, Gelatinase A, TBE-1
Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:MMP-2 activity was measured by its ability to cleave a chromogenic peptide MMP-2 substrate at room temperature. At an MMP-2 concentration of 2.5 μg/ml, 50% cleavage was achieved at an incubation time of approximately 25 minutes.
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文献和实验Expression of Recombinant MMP-28 in Mammalian Cells
The expression of a recombinant MMP in a mammalian cell line can be useful, e.g., for purification of the enzyme, to characterize function of the enzyme, or to uncover its substrates. In this chapter, we have therefore documented
Construction of Recombinant Human Cytomegalovirus
The use of reverse genetics to generate recombinant viruses allows the researcher to investigate the exact functional significance of particular viral genes during the virus life cycle, by means of their deletion or modification in the viral
Expression of Human Collagenase I (MMP-1) andTIMP-1 in a Baculovirus-Based Expression System
Resident cells of tissues are capable of secreting an array of structurally related zinc endopeptidases known as matrix metalloproteinases (MMPs). They initiate the degradation of the surrounding macromolecules of the extracellular matrix
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