CILP2软骨中间层蛋白CILP2抗体

CILP2软骨中间层蛋白CILP2抗体

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  • ¥1380 - 2200
  • LMAI Bio
  • LM-13955R
  • 进口/国产
  • 2025年07月14日
  • ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
  • Rabbit
  • Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, 
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 目录编号

      LM-13955R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      CILP2

    • 抗体名

      软骨中间层蛋白CILP2抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, 

    • 免疫原

      KLH conjugated synthetic peptide derived from human CILP2:1001-1156/1156 

    • 亚型

      IgG

    • 形态

      Lyophilized or Liquid

    • 应用范围

      ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)

    • 浓度

      1mg/ml

    • 保存条件

      Store at -20 °C

    • 规格

      100ul  200ul

    CILP2软骨中间层蛋白CILP2抗体
    英文名称 CILP2
    中文名称 软骨中间层蛋白CILP2抗体
    别    名 Cartilage intermediate layer protein 2 C2; CILP-2; CILP2; CILP2_HUMAN; MGC45771.  
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 细胞生物  免疫学  信号转导  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, 
    产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 126kDa
    细胞定位 细胞浆 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CILP2:1001-1156/1156 
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    Cartilage intermediate layer protein (CILP), an extracellular matrix protein, shows abundant expression in cartilagenous tissues. CILP is expressed as two isoforms, CILP and CILP-2, which are differentially expressed by chondrocytes and induced by TGF∫1. This induction is mediated by Smad3 through direct interactions with cis-elements in the CILP promoter region. TGF∫ also induces elevated chondrocyte extracellular inorganic pyrophosphate (PPi), which promotes the deposition of calcium pyrophosphate dihydrate crystals. The CILP isoforms have been implicated in common musculoskeletal disorders, including osteoarthritis, rheumatoid arthritis and lumbar disc disease.

    Function:
    May play a role in cartilage scaffolding.

    Subcellular Location:
    Secreted > extracellular space > extracellular matrix.

    Tissue Specificity:
    Expressed in articular chondrocytes but not in knee meniscal cartilage cells.

    Post-translational modifications:
    May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.

    Similarity:
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 TSP type-1 domain.

    SWISS:
    Q8IUL8

    Gene ID:
    148113

    Database links:

    Entrez Gene: 148113 Human

    Omim: 612419 Human

    SwissProt: Q8IUL8 Human

    Unigene: 279574 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

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