- ¥1380 - 2200
- LMAI Bio
- LM-12014R
- 进口/国产
- 2025年07月15日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-12014R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
MGLUR1 + MGLUR5
- 抗体名：
促代谢型谷氨酸受体1+5抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human MGLUR1 + MGLUR5:501-600/1194
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | MGLUR1 + MGLUR5 |
| 中文名称 | 促代谢型谷氨酸受体1+5抗体 |
| 别 名 | MGLUR1+MGLUR5; GPRC1A; GPRC1E; GRM1; GRM1A; GRM5; Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 5; mGlu1; mGlu5; MGLUR1; MGLUR1A; MGLUR5; MGLUR5B; GRM1_HUMAN; GRM5_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 合成与降解 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 130kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MGLUR1 + MGLUR5:501-600/1194 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include Metabotropic Glutamate Receptor 5 and Metabotropic Glutamate Receptor 1a. The Group-II receptors in include mGluR2 and mGluR3. Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Subunit: Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 3 family. SWISS: Q13255 Gene ID: 2911 Database links: Entrez Gene: 2911 Human Entrez Gene: 14816 Mouse Entrez Gene: 24414 Rat Omim: 604473 Human SwissProt: Q13255 Human SwissProt: P97772 Mouse SwissProt: P23385 Rat Unigene: 32945 Human Unigene: 391904 Mouse Unigene: 482986 Mouse Unigene: 87787 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: Cerebellum (Mouse) Lysate at 40 ug Primary: Anti- MGLUR1 + MGLUR5 (bs-12014R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 130 kD Observed band size: 150 kD  Sample: Hippocampus (Mouse) Lysate at 40 ug Cerebrum (Mouse) Lysate at 40 ug Primary: Anti- MGLUR1 + MGLUR5 (bs-12014R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 130 kD Observed band size: 150 kD |
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文献和实验10分钟； 10. PB配制的1%戊二醛固定30分钟～2小时后PB漂洗2次，每次10分钟。 按常规电镜标本制作方法进行锇酸后固定、系列乙醇或丙酮脱水、包埋、超薄切片、电子染色和电镜观察。 免疫纳米金与免疫 酶结台的双重染色法电镜图 环氧树脂包埋前免疫纳米金与免疫酶结合的双重染色示大鼠脊髓背角浅层内第7型代谢型谷氨酸受体（mGluR7）和凝集素I―B4结合位点免疫纳之(金染邑标记的mGluR7特异性定位于突触前膜二(箭所示)：免疫酶染色标记的凝集素I―B4结合位．点分布在轴突
盲症的最主要缘由之一，但是它到底有何功效，目前尚未知晓。 在这项新研究中，科学家在小鼠视网膜内寻找到与夜盲蛋白相关的蛋白质。马尔捷米亚诺夫称：“这是第一次发现夜盲蛋白在视觉信号传导途径中的功能角色，并将这种角色与一种更大的分子配合物联系起来。而后者是低光视觉所必需的。”研究者发现，由这一基因表达的蛋白质负责将突触的信号传导机制的关键要素组接起来，为感觉信号的快速、完整传输服务。夜盲蛋白调和了视觉信号的聚集、精准的传输和大分子配合物的突触，这种大分子配合物突触由代谢型谷氨酸受体6亚型（mGluR
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