- ¥780 - 2200
- 康朗生物
- kl-3889R
- 中国/美国/德国
- 2025年07月06日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
- Rabbit
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海康朗生物科技有限公司
- 库存：
大量
- 目录编号：
kl-3889R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
12个月
- 抗体英文名：
NOX2 antibody
- 抗体名：
NADPH氧化酶2抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
- 免疫原：
KLH conjugated synthetic peptide derived from human NOX2:501-570/570
- 亚型：
IgG
- 形态：
冻干粉或液体
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
50ul 100ul 200ul
NOX2 antibody
| 中文名称 | NADPH氧化酶2抗体 |
| 别 名 | AMCBX2; CGD; CGD91-phox; CY24B_HUMAN; CYBB; Cytochrome b 245, beta polypeptide; Cytochrome b(558) beta chain; Cytochrome b(558) subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; GP91 PHOX; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; p22 phagocyte B-cytochrome; P91 PHOX; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit. |
 |
Specific References (6) | bs-3889R has been referenced in 6 publications.
[IF=7.19] Wang, Yabin, et al. "Activation of Liver X receptor improves viability of adipose-derived mesenchymal stem cells (AD-MSCs) to attenuate myocardial ischemia injury through TLR4/NF-κB and Keap-1/Nrf2 signaling pathways." Antioxidants & Redox Signaling ja (2014). WB ; Mouse.
PubMed:24915051
[IF=1.25] Kashiwabara, Yoshiaki, et al. "Immunohistochemical localization of Nox in mouse circumvallate papillae." Tissue and Cell (2015). IHC-P ; Mouse.
PubMed:26603975
[IF=9.83] Wakatsuki, Shuji, et al. "Oxidative stress–dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration." The Journal of Cell Biology (2015): jcb-201506102. IHC-P ; Mouse.
PubMed:26572622
[IF=0.00] Hu, Xiaoqin, et al. "Effects of Resveratrol on Oxidative Stress Injury Induced by Rapid-Pacing in Isolated Rabbit Hearts." Journal of Developing Drugs 3.128 (2014): 2. WB ; Rabbit.
PubMed:0
[IF=25.56] Lagadinou, Eleni D., et al. "BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells." Cell stem cell 12.3 (2013): 329-341. FCM ; Human.
PubMed:23333149
[IF=3.21] Dalaklioglu, Selvinaz, et al. "Metastatic breast carcinoma induces vascular endothelial dysfunction in Balb-c mice: Role of the tumor necrosis factor-?? and NADPH oxidase."Vascular Pharmacology (2013).& Mouse.
PubMed:23933568
|
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NOX2:501-570/570 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections. Function: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Subcellular Location: Membrane. Post-translational modifications: Glycosylated. DISEASE: Defects in CYBB are a cause of chronic granulomatous disease X-linked (XCGD) [MIM:306400]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. Similarity: Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain. SWISS: P04839 Gene ID: 1536 Database links: Entrez Gene: 281112 Cow Entrez Gene: 1536 Human Entrez Gene: 13058 Mouse Entrez Gene: 100008801 Rabbit Entrez Gene: 66021 Rat Omim: 300481 Human SwissProt: O46522 Cow SwissProt: P04839 Human SwissProt: Q61093 Mouse Unigene: 292356 Human Unigene: 200362 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. NOX2也是一个很重要的产生氧自由基的酶。主要存在于甲状腺,前列腺，唾液腺和直肠粘膜中。 |
| 产品图片 |
Sample: Spleen (Mouse) Lysate at 40 ug
Primary: Anti-NOX2 (bs-3889R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 65 kD Observed band size: 65 kD 
Sample: Lymph node (Mouse) Lysate at 40 ug
Primary: Anti-NOX2 (bs-3889R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 65 kD Observed band size: 65 kD 
Tissue/cell: rat brain tissue;4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-NOX2 Polyclonal Antibody, Unconjugated(bs-3889R) 1:200, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated(bs-0295G-Cy3)used at 1:200 dilution for 40 minutes at 37°C. DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei |
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NOX2 antibody
¥780 - 2200
