- ¥1380 - 2200
- LMAI Bio
- LM-11610R
- 进口/国产
- 2025年07月11日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Pig, Cow, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-11610R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Zic2
- 抗体名：
锌指蛋白Zic2抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Pig, Cow, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human Zic2:201-300/532
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | Zic2 |
| 中文名称 | 锌指蛋白Zic2抗体 |
| 别 名 | HPE 5; HPE5; Odd paired homolog Drosophila; Zic 2; Zic family member 2 (odd paired Drosophila homolog); Zic family member 2; ZIC2; ZIC2_HUMAN; Zinc finger protein of the cerebellum 2; Zinc finger protein ZIC 2; Zinc finger protein Zic2. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 神经生物学 信号转导 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Zic2:201-300/532 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2008] Function: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. Subcellular Location: Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus. Post-translational modifications: Phosphorylated. Ubiquitinated by RNF180, leading to its degradation. DISEASE: Defects in ZIC2 are a cause of holoprosencephaly type 5 (HPE5) [MIM:609637]. A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Although severe facial anomalies are common in HPE, patients with ZINC2 mutations have relatively normal faces. Similarity: Belongs to the GLI C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers. SWISS: O95409 Gene ID: 7546 Database links: Entrez Gene: 7546 Human Entrez Gene: 22772 Mouse Entrez Gene: 361096 Rat Omim: 603073 Human SwissProt: O95409 Human SwissProt: Q62520 Mouse Unigene: 653700 Human Unigene: 308936 Mouse Unigene: 64359 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验的Morrissey博士课题组和加拿大渥太华干细胞研究中心的Brand教授课题组合作在Cell Stem Cell发表了通过单细胞蛋白质组学的方法，测定造血干细胞转录因子共表达谱系的时间特异性变化，首次直接提供了造血干细胞命运决定的蛋白质表达数据。研究人员首先对多能干细胞（CD34+ HSPC）分化为红细胞的完整进程（共22天，包括各个进程的红细胞）定时取样（每隔两天）, 在每个时间点对每个单细胞进行标记，通过27种抗体联合标记对应的蛋白质，再通过质谱流式细胞术（CyTOF)同时测定多种蛋白质的表达，这样科学
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Main band of genomic DNA (基因组DNA主带)：密度离心中由一个宽峰度组成，不包括可 见的卫星DNA 组成的分离条带。 Major histocompatibility (主要组织相容性)：包含一个巨大基因簇的大染色体区域，这些基 因编码移植抗体和其它在淋巴细胞表面发现的蛋白质。 Map distance (图距)：用cM(厘米摩尔根)=重组百分率(有时有调整)来测量。 MAR (基质附着位点，有时也称为SAR 即支架附着位点)：附着到核基质
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