重组小鼠Havcr2(Tim-3) 重组蛋白

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专业生产销*(代"售")重组小鼠Havcr2(Tim-3) 重组蛋白，我公司供应的分子生物学试剂品类齐全，且具有优势价格，欢迎新老客户垂询订购。

名称：重组小鼠Havcr2(Tim-3) 重组蛋白
编号：JN1422
规格：10μg|50μg|500μg|1mg
英文名：Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3
品牌：百奥莱博
产地：北京
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Leu22-Ala193在C端含有His标签。

Havcr2/Tim-3质量控制：＞95%(还原性SDS-PAGE)

Havcr2/Tim-3制剂：冻干品

Havcr2/Tim-3保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Havcr2/Tim-3复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Havcr2/Tim-3：
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.

欲咨询购买重组小鼠Havcr2(Tim-3) 重组蛋白，请致电北京百奥莱博科技有限公司，为您提供最全面周到的产品服务，除此之外，我公司正在促销以下产品：
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重组小鼠Havcr2(Tim-3) 重组蛋白关键词：JN1422,重组Havcr2,重组小鼠Havcr2,重组小鼠Tim-3,重组小鼠Havcr2蛋白

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重组小鼠Havcr2(Tim-3) 重组蛋白关键词：JN1422,重组Havcr2,重组小鼠Havcr2,重组小鼠Tim-3,重组小鼠Havcr2蛋白


·重组小鼠TSLPR
编号：JN1405
英文名称：Recombinant Mouse Thymic stromal lymphopoietin protein receptor
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Ala20-Leu233在C端含有His标签。

TSLPR质量控制：＞95%(还原性SDS-PAGE)

TSLPR制剂：冻干品

TSLPR保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TSLPR复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TSLPR ：
The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common γ receptor–like chain (TSLPR-γ) and a common interleukin 7 (IL-7) Rα chain that belongs to the type 1 cytokine receptor family. Transfection of TSLPR cDNA result in only low affinity binding, while cotransfection of the IL-7Rα chain cDNA shows high affinity binding. TSLP and TSLPR play a critical role in the initiation of allergic diseases in mice. The TSLP R cDNA encodes a transmembrane receptor containing 370 amino acids (aa) with two potential N-linked glycosylation sites and a cytoplasmic domain of 104 aa including a single tyrosine residue. TSLPR can mediate signaling of the signal transducer and activator of transcription 5 (Stat5) by TSLP. TSLP R is broadly expressed in the immune and hematopoietic cells, particularly in hematopoietic progenitors and myeloid cells.

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