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- 详细信息
- 文献和实验
- 技术资料
- 库存:
896
- 英文名:
Recombinant Human Clusterin-Like Protein 1
- 保质期:
长期
- 供应商:
北京百奥莱博科技有限公司
- 保存条件:
冻干蛋白置于-20℃以下可长期保存,室温
特别声明:本产品及我公司所售其他产品均为科研类试剂产品,严禁用于药物、医疗及其他非科研用途。
重组人聚集素蛋白1(CLUL1)(簇样蛋白1)怎么卖的品牌:百奥莱博,是优质的重组蛋白产品,用于生化研究,本产品质量好,且极具价格优势,深为用户称道,了解更多重组人聚集素蛋白1(CLUL1)(簇样蛋白1)等重组蛋白产品请联*(代"系")我司咨询订购。
名称:重组人聚集素蛋白1(CLUL1)(簇样蛋白1)怎么卖
编号:JN0823
规格:10μg|50μg|500μg|1mg
英文名:Recombinant Human Clusterin-Like Protein 1
品牌:百奥莱博
产地:北京
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Ala21-Ala442在C端含有His标签。
CLUL1质量控制:>95%(还原性SDS-PAGE)
CLUL1制剂:冻干品
CLUL1保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
CLUL1复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于CLUL1:
Clusterin-Like Protein 1 (CLUL1) is a secreted protein that belongs to the clusterin family. CLUL1 is synthesized as a 466 amino acid precursor that contains a 20 amino acid signal sequence, and a 446 amino acid mature chain. CLUL1 is expressed predominantly by cone photoreceptors of the retina. It has been shown that CLUL1 expression is down-regulated in some forms of retinal disease.
欲咨询购买重组人聚集素蛋白1(CLUL1)(簇样蛋白1)怎么卖,请致电北京百奥莱博科技有限公司,为您提供最全面周到的产品服务,除此之外,我公司正在促销以下产品:
·重组人氧化型低密度脂蛋白受体1(OLR1)
编号:JN0607
英文名称:Recombinant Human Oxidized Low-Density Lipoprotein Receptor 1
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Ser61-Gln273在C端含有His标签。
OLR1质量控制:>95%(还原性SDS-PAGE)
OLR1制剂:冻干品
OLR1保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
OLR1复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于OLR1:
Oxidized Low-Density Lipoprotein Receptor 1 (Ox-LDL Receptor 1) is a secreted, single-pass type II membrane protein which belongs to the C-type lectin superfamily. Ox-LDL Receptor 1 is expressed at high levels in endothelial cells and vascular-rich organs such as placenta, lung, liver, brain, aortic intima, bone marrow, spinal cord and substantia nigra. The expression of Ox-LDL Receptor 1 is induced by inflammatory cytokines such as TNF, IFNG and IL6 by pathological conditions, such as hyperlipidemia, hypertension and diabetes mellitus. Ox-LDL Receptor 1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (OxLDL) by vascular endothelial cells. Ox-LDL Receptor 1 association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. Ox-LDL Receptor 1 also binds to oxLDL, which acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. It also participates in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
重组人聚集素蛋白1(CLUL1)(簇样蛋白1)怎么卖关键词:JN0823,重组人聚集素蛋白1,重组人CLUL1,重组人聚集素蛋白1蛋白,重组人簇样蛋白1
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HR0351 抗体去除液(Western) Antibody removal solution (Western)
SY0087 EGR1-Luc荧光素酶报告基因质粒 EGR1 luciferase reporter plasmid
BTN140411 Orth固定液 Orth Fixative Solution
BTN100814 Oligo dT12-18引物(0.5μg/μL) Oligo dT12-18 Primer
SV1636 SNAP-Cell TMR-Star
YT377 富含GC PCR Buffer GC-rich PCR Buffer
WE0160 超纯dNTP混合液(10 mM) UltraPure dNTP Mix(10 mM each)
BTN130970 柱式革兰氏阳性菌RNA提取试剂盒 Gram positive bacteria RNA Column extraction kit
SV0985 rNTP 混合液
YT024 BL21甘油菌 E.coli BL 21
KFS107 糖元染液
SY0335 胆酸* Sodium Cholate
SV0077 AvrII限制性内切酶 AvrII Restriction Endonuclease
KFS308 端粒酶活性实时定量PCR法检测试剂盒(人)
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YT926 XIAP抑制剂(AT-406) DEBIO 1143
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重组人聚集素蛋白1(CLUL1)(簇样蛋白1)怎么卖关键词:JN0823,重组人聚集素蛋白1,重组人CLUL1,重组人聚集素蛋白1蛋白,重组人簇样蛋白1
·重组人上皮细胞粘附分子(EpCAM)(TROP1)
编号:JN1498
英文名称:Recombinant Human Epithelial cell adhesion molecule
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Gln24-Lys265在C端带有Fc标签。
EpCAM/TROP1质量控制:>95%(还原性SDS-PAGE)
EpCAM/TROP1制剂:冻干品
EpCAM/TROP1保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
EpCAM/TROP1复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于EpCAM/TROP1:
Epithelial Cell Adhesion Molecule (EpCAM) is a signal type I transmembrane glycoprotein that belongs to the EPCAM family. EpCAM is composed of an extracellular domain with one thyroglobulin type-1 domain, a transmembrane domain and a cytoplasmic domain. EpCAM is found on the surface of adenocarcinoma, but not on mesodermal or neural cell membranes. The EpCAM molecule has been shown to function as a homophilic Ca2+ independent adhesion molecule. It may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium as an immunological barrier providing the first line of defense against infection. Defects in EPCAM are a cause of hereditary non-polyposis colorectal cancer type 8 (HNPCC8) and diarrhea type 5 (DIAR5). EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells.
我公司强烈推荐重组蛋白系列产品,热情期待您的咨询选购重组人聚集素蛋白1(CLUL1)(簇样蛋白1)怎么卖。
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文献和实验,通过颗粒胞吐(granuleexocytosis)以单体形式分泌于细胞外。进入靶细胞连接空隙处的穿孔素单体与靶细胞膜相接触,其构型就发生改变,两侧区域暴露,使穿孑L素单体可插入靶细胞膜中,在Ca2+存在下,单体聚集为多聚体,形成许多直径为5-20nm的圆柱形孔。胞膜内外渗透压的差异,使电解质、水分子经由通道进入靶细胞内,导致细胞因胞膜破裂而死亡。此过程与补体激活后通过攻膜复合物裂解靶细胞机制相似。在这一过程中,由于CTL细胞本身可表达并释放A型硫酸软骨素蛋白聚糖,后者与同源限制因子等保护性调节成分一起
细胞表面的辅助受体CD4或CD8分子的胞浆尾部聚集,进而激活与胞浆尾部相连的酪氨酸激酶(Lck, Fyn和ZAP-70等),促使CD3分子胞浆区的免疫受体酪氨酸活化基序(immunoreceptor tyrosine-based activation motif, ITAM)中的酪氨酸(Y)磷酸化。磷酸化的酪氨酸(pY)进一步磷酸化下游含酪氨酸的蛋白,从而引起激酶活化的级联反应(磷脂酰肌醇途径或MAP激酶途径等),最终通过激活转录因子,使其进入细胞核内,结合于调控T细胞增殖和活化的靶基因(如IL-2和IFN
细胞(Ts).当病毒抗原与宿主细胞MHC-1类抗原一起提呈给CD+8的CTL时才能增殖为活化的杀伤细胞,它们杀伤靶细胞受MHC-1类抗原的限制。CTL杀伤靶细胞的机制可能是释放胰蛋白酶样的丝氨酸蛋白酶和细胞毒性淋巴因子(如穿孔素-Perfarin)等,导致靶细胞溶解。CD+4的淋巴细胞约占成熟T淋巴细胞的70%,主要为辅助性T细胞(Th),尚有少数CTL。它们的活化与杀伤功能受细胞表面相应的MHC-Ⅱ类抗原的限制。 Th和Ts是重要的免疫调节细胞,在血中正常比率为2:1。病毒抗原大多为胸腺
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