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- 详细信息
- 文献和实验
- 技术资料
- 库存:
397
- 英文名:
Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A
- 保质期:
长期
- 供应商:
北京百奥莱博科技有限公司
- 保存条件:
冻干蛋白置于-20℃以下可长期保存,室温
特别声明:本产品及我公司所售其他产品均为科研类试剂产品,严禁用于药物、医疗及其他非科研用途。
北京百奥莱博专业生产销*(代"售")北京重组人FcγRIIA现货,我公司供应的分子生物学试剂品类齐全,且具有优势价格,欢迎新老客户垂询订购。
名称:北京重组人FcγRIIA现货
编号:JN1817
规格:10μg|50μg|500μg|1mg
英文名:Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A
品牌:百奥莱博
产地:北京
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Ala36-Ile218在C端含有His标签。
FcγRIIA质量控制:>95%(还原性SDS-PAGE)
FcγRIIA制剂:冻干品
FcγRIIA保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
FcγRIIA复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于FcγRIIA:
Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), which generate multiple isoforms, are recognized. The activating type receptor either has or associates noncovalently with an accessory subunit that has an immunoreceptor tyrosinebased activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG with high affinity and functions during early immune responses, whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three genes for human FcγRII (A, B, and C) and one for mouse (FcγRIIB), encoding type I transmembrane proteins with ITAM motifs (FcγRII A and C) or ITIM motifs (FcγRIIB) in their cytoplasmic domains, have been identified. Human CD32, also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a), FcγRII A or FCGR2A Protein, is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit, FcRγ, CD32a (FcγRII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation, and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
我公司的北京重组人FcγRIIA现货,性价比高,货期短,送货上门,欢迎您来电咨询购买,另外,我公司还生产供应销*(代"售")下列产品:
·重组人TREML2(髓细胞触发受体样蛋白2)
编号:JN1095
英文名称:Recombinant Human Triggering Receptor Expressed on Myeloid Cells-like Protein 2
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Gly19-Ser268在C端带有Fc标签。
TREML2质量控制:>95%(还原性SDS-PAGE)
TREML2制剂:冻干品
TREML2保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
TREML2复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于TREML2:
Trem-like transcript 2 protein (TLT2), also known as Triggering receptor expressed on myeloid cells-like protein 2, TLT2 and C6orf76, is single-pass type I membrane protein. TREML2 contains one Ig-like V-type domain, which can be induced in CD4 T-cell by concanavalin-A. As a cell surface receptor, TREML2 may play a role in the innate and adaptive immune response. TREML2 also acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. It has shown that TREML2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation.
北京重组人FcγRIIA现货关键词:重组人FcγRIIA蛋白,JN1817,重组FcγRIIA,百奥莱博,Recombinant Human Low Affinity Immunoglobulin Gamm
·重组人富含半胱*酸蛋白61(富含半胱*酸血管新生诱导剂61)(Cyr61)(CCN1)
编号:JN1089
英文名称:Recombinant Human Cysteine-rich angiogenic inducer 61
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Thr25-Asp381在C端带有Fc标签。
Cyr61/CCN1质量控制:>95%(还原性SDS-PAGE)
Cyr61/CCN1制剂:冻干品
Cyr61/CCN1保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
Cyr61/CCN1复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于Cyr61/CCN1:
Protein CYR61, also known as CCN family member 1, Cysteine-rich angiogenic inducer 61,Insulin-like growth factor-binding protein 10 , GIG1, CYR61, CCN1 and IGFBP10, belongs to the CCN family, CYR61 is a secreted protein and contains one CTCK (C-terminal cystine knot-like) domain,one IGFBP N-terminal domain,one TSP type-1 domain andone VWFC domain. CYR61 promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. CYR61 plays important roles in inflammation and tissue repair. CYR61 is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers.
北京重组人FcγRIIA现货关键词:重组人FcγRIIA蛋白,JN1817,重组FcγRIIA,百奥莱博,Recombinant Human Low Affinity Immunoglobulin Gamm
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ALH241 2×Pfu PCR MasterMix
YT547 丙*酸脱*酶 Alanine Dehydrogenase (Crude Enzyme)
WE0274 蛋白标准溶液BSA Protein Standard Solution(BSA)
BTN130950 革兰氏阴性菌DNA提取试剂盒(Southern级) Gram negative bacteria DNA extraction kit(Southern Grade)
SV1276 Quick-Load Purple 1 kb DNA Ladder
YT134 TUNEL检测阳性对照制备试剂盒 Positive control preparation kit for TUNEL detection
KFS219 Caspase-3蛋白检测试剂盒 Caspase 3 Detection Assay(Western Blot)
SY0459 牛胰岛素 Insulin (From Bovine)
SV0376 FseI限制性内切酶 FseI Restriction Endonuclease
WE0126 防污染多重PCR MasterMix(含UNG酶) Multiplex PCR MasterMix(UNG)
HR0368 SDS-PAGE 上样 Buffer SDS-PAGE sample Buffer
SY0097 Pax6-Luc荧光素酶报告基因质粒 Pax6 luciferase reporter plasmid
BTN131283 多聚甲醛-*氧化*固定液 Polyoxymethylene NaOH Fixative Solution
BTN100947 环状DNA全基因组扩增试剂盒 Circular DNA Whole Genome Amplification Kit
SV1646 SNAP-Cell 启动试剂盒
YT388 dTTP溶液(100mM) dTTP Solution
BTN131070 牛血清白蛋白标准品(BSA标准品)(2mg/mL) BSA Standard
BTN130972 miRNA分离纯化试剂盒(凝胶法) miRNA isolation Kit(Gel method)
SV0999 Hemo KlenTaq 反应缓冲液套装
北京百莱博科技有限公司是重组蛋白产品的专业生产供应销*(代"售")商,恭候您的咨询选购北京重组人FcγRIIA现货。
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文献和实验应答,产生效应T细胞,伤害相应自身组织细胞。(4) 免疫抑制细胞产生TGF�β,抑制辅助性T细胞(Th)及细胞毒性T细胞(CTL)功能。如果免疫抑制细胞数量减低、功能减弱,可导致自身反应性T细胞活化、增殖及自身抗体的产生。(5) B细胞FcγRIIB为抑制性受体,正常情况下与其它兴奋性受体,如FcγRIIA和FcγRIIIA保持动态平衡,如果平衡被破坏,即可出现B细胞外周耐受失调,被激活而产生自身抗体。(6) Fas和FasL通路介导的激活诱导细胞死亡异常,不能有效地促使自身反应性T细胞凋亡,导致自身免
,或者 λ 链)。 Anti-IgG (H+L) 抗体比只抗片段的抗体识别更多的抗原表位,适合普通的免疫检查过程。 Anti-IgG , Fc/ Fc γ fragment specific 这类抗体和 IgG 重链的 Fc 部分反应。它们通过 ELISA 检测,和 / 或针对 Fab 片段吸附测试。某些情况下,这类抗体需要额外检测和 / 或吸收处理来降低 IgM 和 或 IgA 的交叉反应。在这种情况下( 抗人,抗鼠和抗大鼠 ),抗体标有“抗 IgG ( Fc γ )”,表示
损伤。61543;IgG占成人血清中抗体总量的75%以上,是人类血清中主要的一类抗体,由B细胞产生,其功能结构也是研究最清楚的。它主要的生理功能有1、中和毒素和病毒2、凝集和沉淀抗原3、激活补体4、通过特异的膜受体(Fc单克隆抗体技术的应用是现代生物科学领域中的重要进展之一。单克隆抗(Monoclonalantibody,简称McAb)具有广泛的应用价值,它为生物学和医学等自然科学的研究开辟了新的途经。二、第二代单克隆抗体经过基因重组的嵌合或人源化单克隆抗体1、嵌合抗体指用人的恒定区取代小鼠的恒定区,保留
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