- ¥780 - 2200
- LMAI Bio
- LM-0687R
- 进口/国产
- 2026年06月05日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Pig,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-0687R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
OAS1
- 抗体名：
寡腺苷酸合成酶-1
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Pig,
- 免疫原：
KLH conjugated synthetic peptide derived from human OAS1:1-100/400
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | OAS1 |
| 中文名称 | 寡腺苷酸合成酶-1 |
| 别 名 | 2',5'-oligoadenylate synthetase 1; (2 5')oligo(A) synthetase 1 ; (2 5')oligo(A) synthetase 1; 2 5 Oligoadenylate Synthetase 1; 2 5A synthetase 1; 2' 5' oligo A synthetase 1; 2' 5' oligoadenylate synthetase 1; 2' 5' oligoisoadenylate synthetase 1; 2'5' oligo A synthetase 1; 2'5' oligoadenylate synthetase 1; 2'5' oligoisoadenylate synthetase 1; E18/E16; IFI 4; IFI4; OAS 1; OIAS; OIASI; p46/p42 OAS; OAS1_HUMAN. |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Pig, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40/46kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OAS1:1-100/400 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This protein is an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. Subunit: Monomer. Homotetramer. Subcellular Location: Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. Similarity: Belongs to the 2-5A synthase family. SWISS: P00973 Gene ID: 4938 Database links: Entrez Gene: 347699 Cow Entrez Gene: 4938 Human Entrez Gene: 397570 Pig Entrez Gene: 192281 Rat Omim: 164350 Human SwissProt: P00973 Human SwissProt: P11928 Mouse SwissProt: Q29599 Pig SwissProt: Q05961 Rat Unigene: 524760 Human Unigene: 10383 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 用于免疫调控通路的研究。主要用于系统性红斑狼疮方面的研究。 |
| 产品图片 |  Sample: Hela(Human) Cell Lysate at 40 ug Primary: Anti-OAS1 (bs-0687R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40/46 kD Observed band size: 40 kD  Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-OAS1 Polyclonal Antibody, Unconjugated(bs-0687R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
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文献和实验2＇－5＇-寡腺苷酸合成酶 2＇-5＇-oligoadenyla－te synthetase
I． M． Kerr等（ 1978）在干扰素处理过的细胞提取液中发现的酶，在双链 RNA和 ATP的存在下，催化合成普通核酸中见不到的具有 2＇－ 5＇磷酸二酯键的寡核苷酸（ P） PPA2 ＇ （ P5＇ A） n，即 2＇－ 5＇ - 寡腺苷酸合成酶（ 2－ 5A）。在各种细胞和组织中均可发现此酶的活性，在经过干扰素处理后活性显著上升， 2－ 5A可以活化 RNA分解酶，从而分解 mRNA，据此可以抑制非细胞系的寄主和病毒的蛋白合成。向细胞内加入 2－ 5A会抑制
人2,5寡腺苷酸合成酶 （2,5-OAS）酶联免疫分析（ELISA）
人 2,5寡腺苷酸合成酶 （2,5-OAS） 酶联免疫 分析（ ELISA ） 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本中 2,5寡腺苷酸合成酶 （2,5-OAS）的 含量。 实验原理 ： 本试剂盒应用 双抗体 夹心法测定 标本 中 人2,5 寡腺苷酸合成酶 （ 2,5-OAS ） 水平。用纯化的 人2,5 寡腺苷酸合成酶 （ 2,5-OAS ）抗体 包被微孔板，制成固相
一种特殊的因子，使抗病毒蛋白（AVP）基因解除抑制，转录并翻译出AVP，主要是蛋白激酶、2�-5�A合成酶、磷酸二酯酶，这些酶与发挥抗病毒活性有密切关系。其中二种酶须经双股RNA及ATP激活，一为蛋白激酶，激活后可使合成蛋白质的起动因子2（eIF-2）同磷酸化而失活，抑制蛋白质合成；另一种为2�-5�A合成酶，活化后催化合成2�-5�寡腺苷酸，再激活潜在的核酸内切酶，使病毒mRNA降解，抑制病毒蛋白合成。此外，磷酸二酯酶能降解2�-5�A，又能除去tRNA的CCA末端，抑制蛋白合成。 干扰
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