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CD44v10 antibody

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  • ¥1380 - 2200
  • 康朗生物
  • 中国/美国/德国
  • 2025年07月13日
  • WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500
  • Rabbit
  • Human
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 供应商：

      上海康朗生物科技有限公司

    • 库存：

      大量

    • 目录编号：

      kl-13975R

    • 克隆性：

      多克隆

    • 抗原来源：

      Rabbit

    • 保质期：

      12个月

    • 抗体英文名：

      CD44v10 antibody

    • 抗体名：

      CD44V10抗体

    • 宿主：

      Rabbit

    • 适应物种：

      Human

    • 免疫原：

      KLH conjugated synthetic peptide derived from human CD44v10:218-223+472-477/742, 223=T -> N <Extracellular>

    • 亚型：

      IgG

    • 形态：

      冻干粉或液体

    • 应用范围：

      WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500

    • 浓度：

      1mg/ml

    • 保存条件：

      -20 °C

    • 规格：

      100ul 200ul

    CD44v10 antibody
    中文名称 CD44V10抗体
    别    名 IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III  
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 肿瘤  细胞生物  干细胞  细胞粘附分子  细胞表面分子  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 52/82kDa
    细胞定位 细胞膜 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human CD44v10:218-223+472-477/742, 223=T -> N <Extracellular>
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008].

    Function:
    Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

    Subunit:
    Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment.

    Subcellular Location:
    Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges.

    Tissue Specificity:
    Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

    Post-translational modifications:
    Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. 
    N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638. 
    Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.

    Similarity:
    Contains 1 Link domain.

    SWISS:
    P16070

    Gene ID:
    960

    Database links:

    Entrez Gene: 960 Human

    Omim: 107269 Human

    SwissProt: P16070 Human

    Unigene: 502328 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
     
    产品图片 产品细节图片1
    Sample: 
    293T(Human) Cell Lysate at 40 ug
    Primary: Anti-CD44v10 (bs-13975R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 52/82 kD
    Observed band size: 52 kD

    产品细节图片2
    Blank control (blue line): U251 (fixed with 70% ethanol overnight at 4℃ and then permeabilized with 0.1% PBS-Tween for 20 min at room temperature). 
    Primary Antibody (green line): Rabbit Anti-CD44v10 antibody (bs-13975R),Dilution: 0.2 μg /10^6 cells; 
    Isotype Control Antibody (orange line): Rabbit IgG .
    Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE,Dilution: 1μg /test. 

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    图标文献和实验
    相关实验

    • CD44/CD44R分子

      CD44/CD44R 分子       CD44 常用单克隆抗体或代号： GRHL1,Hermes,F10- 44- 2(Pgp- 1H- CAM,ECM- RⅢ) 主要表达细胞： Leu,上皮,Fb,RBC[AS] 分子质量(kDa)和结构： gp80- 95 功    能： 粘附ECM,T细胞活化,淋巴细胞归位受体,归位到HEV   CD44R 常用单克隆抗体或代号： FM11,24

    • CD44

             对CD44的研究时间较长、较深入亦较广泛。已知其为分布极为广泛的细胞表面跨膜糖蛋白，主要参与异质性粘附，即肿瘤细胞与宿主细胞和宿主基质的粘附，异质性粘附在肿瘤细胞侵袭转移中起促进作用。 人类CD44基因位于11号染色体短臂，全长约50kb，共由20个高度保守的外显子组成，每个外显子长度70-210bp不等，中间由长短不一的内含子分隔。CD44基因的20个外显子按照转录方式不同可分为组成型外显子（C）和变异型拼接外显子（V）两大类。组成型外显子共有10个，存在

    • PCR Analysis of CD44 Variants in Tumors

      The CD44 molecule is a transmembrane glycoprotein, it is an acidic, sul fated protein that contains multiple phosphoserine residues and several intrachain disulfide bonds. It is essentially composed of a 37-kDa protein core highly glycosylated

    查看更多相关实验 >
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