TXNDC4 antibody

TXNDC4 antibody

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  • ¥1380 - 2200
  • 康朗生物
  • 中国/美国/德国
  • 2025年07月15日
  • IHC-P=1:400-800 IHC-F=1:400-800
  • Rabbit
  • Human, Mouse, Rat, Dog, Pig, Cow,
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    • 详细信息
    • 技术资料
    • 供应商

      上海康朗生物科技有限公司

    • 库存

      大量

    • 目录编号

      kl-3838R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      12个月

    • 抗体英文名

      TXNDC4 antibody

    • 抗体名

      内质网蛋白44抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Mouse, Rat, Dog, Pig, Cow,

    • 免疫原

      KLH conjugated synthetic peptide derived from human TXNDC4:251-350/409

    • 亚型

      IgG

    • 形态

      冻干粉或液体

    • 应用范围

      IHC-P=1:400-800 IHC-F=1:400-800

    • 浓度

      1mg/ml

    • 保存条件

      -20 °C

    • 规格

      100ul 200ul

    TXNDC4 antibody
    中文名称 内质网蛋白44抗体
    别    名 Endoplasmic reticulum resident protein 44; Endoplasmic reticulum resident protein 44 kDa; Endoplasmic reticulum resident protein ERp44; ER protein 44; ERP44; KIAA0573; PDIA10; Protein disulfide isomerase family A, member 10; Thioredoxin domain containing 4 (endoplasmic reticulum); Thioredoxin domain containing protein 4; UNQ532/PRO1075; ERP44; ERP44_HUMAN.  
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 细胞生物  免疫学  染色质和核信号  转录调节因子  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, 
    产品应用 IHC-P=1:400-800 IHC-F=1:400-800 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 44kDa
    细胞定位 细胞浆 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human TXNDC4:251-350/409 
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum.

    Function:
    Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum.

    Subunit:
    Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration.

    Subcellular Location:
    Endoplasmic reticulum lumen.

    Similarity:
    Contains 1 thioredoxin domain.

    SWISS:
    Q9BS26

    Gene ID:
    23071

    Database links:

    Entrez Gene: 23071 Human

    Entrez Gene: 506157 Cow

    Entrez Gene: 474781 Dog

    Entrez Gene: 76299 Mouse

    Entrez Gene: 100192437 Pig

    Entrez Gene: 298066 Rat

    Omim: 609170 Human

    SwissProt: Q3T0L2 Cow

    SwissProt: Q9BS26 Human

    SwissProt: Q9D1Q6 Mouse

    Unigene: 154023 Human

    Unigene: 317701 Mouse

    Unigene: 2459 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
     
    产品图片 TXNDC4 antibody
    Tissue/cell: mouse brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; 
    Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37∩ for 20 min; 
    Incubation: Anti-TXNDC4 Polyclonal Antibody, Unconjugated(bs-3838R) 1:200, overnight at 4∑C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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