名称:北京重组人*离子细胞内通道蛋白4(CLIC4)厂商 编号:JN0860 产地:国产|进口 英文名:Recombinant Human Chloride Intracellular Channel Protein 4 本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Lys253在N端含有His标签。
CLIC4质量控制:>95%(还原性SDS-PAGE)
CLIC4制剂:液体
CLIC4保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于CLIC4: Chloride Intracellular Channel Protein 4 (CLIC4) is a 253 amino acid single-pass membrane protein that localizes to both the nucleus and the cytoplasm and contains one GST C-terminal domain. CLIC4 is expressed in various tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). CLIC4 acts as a monomer which is able to form selective ion channels in target proteins, thus facilitating the transport of chloride and other ions. CLIC4 is believed to have a role in apoptosis and is able to translocate to the nucleus under stress conditions. CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis.
关于TNFRSF10C: Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.