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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
2-Acetylphenothiazine; 2-APT
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/100 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥220.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥200.0 |
| 规格： | 500 mg | 产品价格： | ￥400.0 |
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ML171
CAS No. : 6631-94-3
MCE 国际站：ML171
产品活性：ML171 (2-Acetylphenothiazine;2-APT) 是有效的选择性 NADPH 氧化酶 1 (Nox1) 抑制剂，可阻止 Nox-1 依赖性的 ROS 产生，在 HEK293-Nox1 验证试验中的 IC50 值为 0.25 μM。
研究领域：Metabolic Enzyme/Protease
作用靶点：NADPH Oxidase
In Vitro: Nox1-dependent ROS generation has been shown to play a pivotal role in cell signaling, cell growth, angiogenesis, motility and blood pressure regulation. ML171 strongly blocks ROS generation in HT29 cells (IC50=0.129 μM) and only increasing over-expression of Nox1 can overcome the blockage of ROS generation caused by ML171 treatment in HEK293 cell system reconstituted with all the components required Nox1-dependent ROS generation. ML171 efficiently blocks ROS production measured by carboxy-H2-DCFDA staining as well as DPI used as a positive control. When ML171 is tested in HEK293-Nox1 reconstituted cell system, higher potency in blocking Nox1-dependent ROS generation is observed compared with the parental compound.
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文献和实验,32765,39396,42087,42364, 43763,44502, 46983 片段长度: 6631, 6236,5733,4920,4091,2691,2481,2419,2360,1913, 1712, 1520,1399,1268,956,739,493,458,277,170,35 ApaI 1site:
Genome‐Wide Annotation and Quantitation of Translation by Ribosome Profiling
miRNeasy RNA isolation kit (Qiagen) 15 mg/ml GlycoBlue 10 mM Tris⋅Cl, pH 8 ( appendix 22
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