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- SERbio
- 进口
- T4042
- 2025年07月09日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温
- 保质期：
1年
- 英文名：
Talabostat mesylate
- 库存：
10000
- 供应商：
南京赛泓瑞
- CAS号：
150080-09-4
- 规格：
250.342935528121
产品名称：Talabostat mesylate
Talabostat mesylate生物活性：
| Talabostat mesylate is an orally active, specific inhibitor of dipeptidyl peptidases with IC50 of 1 nM for DPP4, including tumor-associated fibroblast activation protein. |
Talabostat mesylate制备储备液：
| 浓度溶解体积质量 | 1mg | 5mg | 10mg |
| 1mM | 2.1032mL | 10.5159mL | 21.0318mL |
| 5mM | 0.4206mL | 2.1032mL | 4.2064mL |
| 10mM | 0.2103mL | 1.0516mL | 2.1032mL |
| 50mM | 0.0421mL | 0.2103mL | 0.4206mL |
Talabostat mesylate临床数据( 数据源于：http:// clinicaltrials.gov）
Conversion of different model animals based on BSA（Value based on data from FDA Draft Guidelines）
Animal A (mg/kg)=Animal B（mg/kg）multiplied by AnimalBm系数/AnimalAm系数
For example, to modify the dose of resveratrol uesd for a mouse(22.4mg/kg) to a dose based on the BSA for a rat, multiply 22.4mg/kg by the Km factor for a mouse and zhen divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2mg/kg
南京赛泓瑞生物科技有限公司是专业从事生化试剂、分子生物学试剂、实验耗材及实验仪器研发、销售、服务为一体的专业性生物科技公司。本着服务科学的理念，赛泓瑞建立了生命科学研究工具的研发、生产、销售及技术服务平台，现已有数万余种产品，并每年不断开发新产品，为广大的生命科学研究人员、医学、药学、农业、环保等的科研人员提供科研工具性产品及技术服务.
经营范围：抑制剂、ELISA试剂盒、原代细胞和细胞株、化学试剂、蛋白、抗体、分子试剂和试剂盒。
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文献和实验Detection of BCR-ABL Mutations and Resistance to Imatinib Mesylate
The major mechanism of imatinib resistance for patients with chronic myeloid leukemia (CML) is clonal expansion of leukemic cells with mutations in the Bcr-Abl fusion tyrosine kinase that reduce the capacity of imatinib to inhibit kinase
-4 and C-5 centers ( 3 ). After formatron of the mesylate, from the recycled material the amine function is introduced through azrde displacement of the mesylate, followed by reduction ( 4 ) and protectron with the t -BOC group. Finally, the lactone
Inhibitors of Cellular Signaling Targets: Designs and Limitations
. Because of their central role in cellular signaling, as well as their primary role in disease progression, protein kinases are attractive therapeutic targets (2 ,3 ). Seven molecules targeting protein kinases, imatinib mesylate (Gleevec) and trastuzumab (Herceptin
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