HCV Core 16.8kDa

HCV Core 16.8kDa

CATALOGUE NUMBER

HCV-011

INTRODUCTION

HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae.
HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).

DESCRIPTION

Recombinant HCV Core produced in E.coli is a non-glycosylated polypeptide chain having a molecular mass of 16.8 kDa and fused to a His tag at N-terminus.

SOURCE

Escherichia Coli.

PHYSICAL APPEARANCE

Sterile Filtered White lyophilized (freeze-dried) powder.

FORMULATION

Lyophilized from 1mg/ml in 1xPBS pH-7.4 and 0.02% SDS.

SOLUBILITY

It is recommended to reconstitute the lyophilized HCV Core in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

STABILITY

HCV Core although stable at room temperature for 4 weeks, should be stored below -18°C. 
Please prevent freeze thaw cycles.

PURITY

Greater than 95.0% as determined by SDS-PAGE.

USAGE

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.