英文名称human CD11b-FITC
中文名称FITC标记小鼠抗人CD11b单克隆抗体 别 名Antigen CD11b p170; CD11 antigen like family member B; CD11b antigen; CD49d; Cell surface glycoprotein MAC 1 alpha subunit; Cell Surface Glycoprotein MAC1 Alpha Subunit; Complement Component Receptor 3 Alpha; CR 3 alpha chain; CR3 Alpha Chain; CR3A; Integrin Alpha M; integrin alpha M complement component 3 receptor 3 subunit; Leukocyte Adhesion Receptor MO1; MAC 1; MAC1A; MGC117044; MO1A; Neutrophil Adherence Receptor; Cd11b; CD11b/CD18; F730045J24Rik; Ly-40; ITGAM; CR3A; ITAM_HUMAN; FITC anti-human CD11b;
规格25T 100T
研究领域肿瘤 细胞生物 神经生物学 信号转导 干细胞 细胞粘附分子 细胞类型标志物 淋巴细胞
抗体来源Mouse
克隆类型Monoclonal
交叉反应 Human,
产品应用Flow-Cyt=20ul/Test (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量125kDa
细胞定位细胞膜
性 状Liquid
免 疫 原:
亚 型IgG1
纯化方法affinity purified by Protein G
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Function:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subcellular Location:
Membrane.
Tissue Specificity:
Predominantly expressed in monocytes and granulocytes.
Similarity:
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6). Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
SWISS:
P11215
Gene ID:
3684
Database links:
Entrez Gene: 3684 Human
Omim: 120980 Human
SwissProt: P11215 Human
Unigene: 172631 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
Flow cytometry staining of normal human peripheral blood cells with CD11b/FITC (bsm-30073M-FITC)(Red histogram) or Mouse IgG1 Isotype Control (FITC Conjugate)(C03-11001)(Blue histogram) . Total cells were used for analysis.