Dexamethasone phosphate disodi

Dexamethasone phosphate disodium

产品活性：Dexamethasone phosphate disodium is a glucocorticoid receptor agonist.

研究领域：GPCR/G Protein

作用靶点：Glucocorticoid Receptor

In Vitro: Dexamethasone regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response^[1]. Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC₅₀ of 2.2 nM. Dexamethasone (EC₅₀=36 nM) induces transcription of the β₂-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC₅₀=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release^[2].

In Vivo: Treatment with Dexamethasone at a dose of 2×5 mg/kg efficiently inhibits lipopolysaccharide (LPS)-induced inflammation. In our experimental system, treatment with a single dose of Dexamethasone 10 mg/kg (i.p.) significantly decreases recruitment of granulocytes as well as spontaneous production of oxygen radicals compared with animals expose to LPS and injected with solvent alone (saline). The effects are statistically significant when administered both 1 h before and 1 h after inhalation of LPS. The number of granulocytes in BALF decreased to levels comparable to healthy animals (given an aerosol of water)^[3]. Rats treated with Dexamethasone consume less food and weighed less than control rats. Treated rats also weigh less than pair-fed animals though their food intake is similar. Five days of Dexamethasone injection result in a significant increase in both the liver mass (+42%) and the liver to body weight ratio (+65%). The wet weight of gastrocnemius muscle decreases 20% after 5 days of treatment, but it remains unaffected relative to body weight (g/100 g body weight), indicating that muscle weight loss paralleled body weight loss^[4].

相关产品：FDA-Approved Drug Library Mini  |  GPCR/G Protein Compound Library  |  FDA-Approved Drug Library  |  Bioactive Compound Library Plus  |  Dexamethasone  |  Hydrocortisone  |  Mifepristone  |  Corticosterone  |  Prednisolone  |  Methylprednisolone  |  Prednisone  |  Budesonide  |  (20S)-Protopanaxatriol  |  Fluticasone propionate  |  Triamcinolone  |  Mapracorat  |  AL 082D06  |  Cortisone  |  Glucocorticoid receptor agonist  |  Betamethasone  |  Ciclesonide  |  AZD7594  |  Beclometasone dipropionate  |  AZD9567  |  Cort108297  |  Flunisolide  |  Fluocinolone Acetonide

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