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Recombinant Human Sialate O-Acetylesterase
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北京百奥莱博科技有限公司
特别声明:本产品及我公司所售其他产品均为科研类试剂产品,严禁用于药物、医疗及其他非科研用途。
JN0808型重组人SIAE(唾液酸O-乙酰酯酶)特价促销是高品质的分子生物学试剂产品,由北京百奥莱博供应,用于生化研究,本产品质量好,且极具价格优势,深为用户称道,了解更多重组人SIAE(唾液酸O-乙酰酯酶)等分子生物学试剂产品请联系我司咨询订购。
名称:JN0808型重组人SIAE(唾液酸O-乙酰酯酶)特价促销
编号:JN0808
品牌:百奥莱博
产地:国产|进口
规格:10μg|50μg|500μg|1mg
英文名:Recombinant Human Sialate O-Acetylesterase
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Ile24-Lys523在C端含有His标签。
SIAE质量控制:>95%(还原性SDS-PAGE)
SIAE制剂:液体
SIAE保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于SIAE:
Sialate O-Acetylesterase (SIAE) belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. SIAE is widely expressed with high expression levels in the testis, prostate, and colon. SIAE catalyzes N-acetyl-O-acetylneuraminate and H2O to N-acetylneuraminate and acetate. SIAE removes O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. SIAE down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for immunological tolerance. Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.
关于JN0808型重组人SIAE(唾液酸O-乙酰酯酶)特价促销的更详细说明,请致电我公司咨询,我们将以最饱满的热情为您提供解答,此外,我公司专业供应下列产品:
·重组人前折叠素4(PFDN4)
编号:JN0859
英文名称:Recombinant Human Prefoldin Subunit 4
规格:10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Ser134在N端含有His标签。
PFDN4质量控制:>95%(还原性SDS-PAGE)
PFDN4制剂:冻干品
PFDN4保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
PFDN4复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于PFDN4:
Prefoldin Subunit 4 (PFDN4) is a heterohexameric chaperone protein that belongs to the prefoldin subunit beta family. The complex of PFDN4, consisting of two PFD-alpha type and four PFD-beta type subunits, forms a double beta barrel assembly with six protruding coiled-coils. PFDN4 binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly.
·重组小鼠ULBP-1
编号:JN1375
英文名称:Recombinant Mouse UL16 Binding Protein-1/NKG2D ligand 1
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Pro26-Thr211在C端含有His标签。
ULBP-1质量控制:>95%(还原性SDS-PAGE)
ULBP-1制剂:冻干品
ULBP-1保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
ULBP-1复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于ULBP-1:
Mouse ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocomp*(代"a")tibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or interact with beta2-microglobulin. It can activate multiple signaling pathways in primary NK cells, gamma delta T cells, and CD8+ alpha beta T cells, resulting in the production of cytokines and chemokines.ULBP1 is expressed in wide range of tissues including heart, brain, lung, liver, bone marrow and some tumor cells, T-cells, B-cells, As an unconventional member of the MHC class I family, ULBP1 is able to interact with soluble CMV glycoprotein UL16 in CMV infected cells. The interaction with UL16 blocked the interaction with the NKG2D receptor, and thus might escape the immune surveillance. Furthermore, UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. The ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells.
JN0808型重组人SIAE(唾液酸O-乙酰酯酶)特价促销关键词:重组人唾液酸O-乙酰酯酶,重组人SIAE,JN0808,重组人SIAE蛋白,重组SIAE
·重组食蟹猴细胞程序死亡蛋白1(PD-1)
编号:JN1539
英文名称:Recombinant Cynomolgus monkey Programmed Cell Death Protein 1
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Pro21-Gln167在C端含有His标签。
PD-1质量控制:>95%(还原性SDS-PAGE)
PD-1制剂:冻干品
PD-1保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
PD-1复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于PD-1:
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
JN0808型重组人SIAE(唾液酸O-乙酰酯酶)特价促销关键词:重组人唾液酸O-乙酰酯酶,重组人SIAE,JN0808,重组人SIAE蛋白,重组SIAE
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