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- 保存条件:
冷藏
- 保质期:
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- 英文名:
Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B
- 库存:
952
- 供应商:
北京百奥莱博科技有限公司
特别声明:本产品及我公司所售其他产品均为科研类试剂产品,严禁用于药物、医疗及其他非科研用途。
北京百奥莱博专注于生命科学和生物技术领域,致力于为客户提供包括北京重组人FcγRIIB现货供应在内的一系列分子生物学试剂产品,并提供一系列相关的技术服务。
名称:北京重组人FcγRIIB现货供应
品牌:百奥莱博
编号:JN0568
英文名:Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B
产地:国产|进口
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Thr43-Pro217在C端含有His标签。
FcγRIIB质量控制:>95%(还原性SDS-PAGE)
FcγRIIB制剂:冻干品
FcγRIIB保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
FcγRIIB复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于FcγRIIB:
FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding. Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis. Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation. FcγRIIB may also be a target for monoclonal antibody therapy for malignancies. FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors.
更多有关北京重组人FcγRIIB现货供应的价格及使用说明等,请联系我们的业务经理王欣女士咨询,我公司还销*(代"售")以下产品:
·重组人Long-R3-IGF1
编号:JN0211
英文名称:Recombinant Human LR3 Insulin-Like Growth Factor I
规格:10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备,目的基因编码的Gly49-Ala118表达纯化而来。
IGF1(Long-R3-IGF1)质量控制:>95%(还原性SDS-PAGE)。
IGF1(Long-R3-IGF1)制剂:冻干品
IGF1(Long-R3-IGF1)保存:
冻干蛋白可在-20℃长期保存,室温也可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天。
复溶后建议分装冻存在-20℃,可保存3个月,应避免反复冻融。
IGF1(Long-R3-IGF1)复溶:
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存,避免反复冻融。
关于IGF1(Long-R3-IGF1):
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.
北京重组人FcγRIIB现货供应关键词:Recombinant Human Low Affinity Immunoglobulin Gamm,JN0568,重组FcγRIIB,百奥莱博,重组人FcγRIIB蛋白
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北京重组人FcγRIIB现货供应关键词:Recombinant Human Low Affinity Immunoglobulin Gamm,JN0568,重组FcγRIIB,百奥莱博,重组人FcγRIIB蛋白
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北京百莱博科技有限公司专业生产分子生物学试剂产品,欢迎来电咨询选购北京重组人FcγRIIB现货供应。
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文献和实验Induction of Tolerogenic Dendritic Cells by NF-B Blockade and Fc Receptor Modulation
and in vivo , that NF-κB blockade on DCs by andrographolide or rosiglitazone can significantly enhance the tolerogenic capacity of DCs. Furthermore, we have observed that expression ratio of the activating FcγRIII or the inhibitory FcγRIIb is determinant
Novel Opportunities for Therapeutic Targeting in Systemic Autoimmune Diseases
) antagonists, and FcγRIIB receptor antagonists. Also promising is the current interest centered on the development of inhibition of signal transduction pathways, such as pharmacological inhibitors that act at various levels of signal transduction pathways.
应答,产生效应T细胞,伤害相应自身组织细胞。(4) 免疫抑制细胞产生TGF�β,抑制辅助性T细胞(Th)及细胞毒性T细胞(CTL)功能。如果免疫抑制细胞数量减低、功能减弱,可导致自身反应性T细胞活化、增殖及自身抗体的产生。(5) B细胞FcγRIIB为抑制性受体,正常情况下与其它兴奋性受体,如FcγRIIA和FcγRIIIA保持动态平衡,如果平衡被破坏,即可出现B细胞外周耐受失调,被激活而产生自身抗体。(6) Fas和FasL通路介导的激活诱导细胞死亡异常,不能有效地促使自身反应性T细胞凋亡,导致自身免
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