- $830
- Alomone
- 以色列
- ESP-652
- 2025年07月12日
- 见官方网站
- 见说明书
- 见官方网站
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- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
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- 适应物种：
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- 保质期：
6个月
- 抗原来源：
见说明书
- 目录编号：
ESP-652
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
见说明书
- 应用范围：
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- 浓度：
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- 靶点：
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- 抗体英文名：
Human proNGF Premium Research Pack
- 抗体名：
Human proNGF Premium Research Pack
- 规格：
8 Vials
Human proNGF Premium Research Pack
All You Need for proNGF ResearchCat #: ESP-652
8 Vials
Alomone Labs is pleased to offer the Human proNGF Premium Research Pack (#ESP-652). The Research Pack contains all you need for human proNGF research: Antibodies to proNGF and its receptor, and recombinant proteins all in one economical package!
- Compounds
- Scientific Background
- Related Products
| Product Name | Cat # | Size |
|---|---|---|
Anti-p75NTR (extracellular) |
ANT-007 | 1 x 0.2 ml |
Anti-proNGF |
ANT-005 | 1 x 0.2 ml |
Guinea pig Anti-proNGF |
AGP-031 | 1 x 0.2 ml |
human proNGF (cleavage resistant) |
N-285 | 1 x 10 µg |
human proNGF |
N-280 | 1 x 25 µg |
Note A guinea pig polyclonal antibody (#AGP-031) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
Neurotrophins are synthesized as pro-forms that can be cleaved either intracellularly to release mature, secreted ligands, or extracellularly by various proteases such as plasmin, furin, PC1/3, PC7, and PACE 4.1,2,5 The immature precursor has a prodomain of 103 amino acids, which was thought to have a role in the folding and sorting of the mature NGF into the various secretion pathways.
It was recently reported that proNGF, binds p75NTR receptor preferentially over TrkA, and this selective binding of proNGF to p75NTR leads to apoptotic death of cells that express both TrkA and p75NTR. However, mature NGF binds and activates both receptors, with resulting promotion of cell survival due to the TrkA-mediated survival signal overriding p75NTR -mediated apoptotic signal.3,4
Since pro- and mature neurotrophins seem to elicit opposite functional effects, by differential interactions with Trks and p75NTR receptors, extracellular cleavage represents a new way to control the synaptic functions of neurotrophins.
It was demonstrated that proNGF from injured spinal cord extracts, is active and induce apoptosis among oligodendrocytes, and apoptosis can be blocked by a proNGF-specific antibody.6
Finally, proNGF was demonstrated as the predominant form in mouse, rat, and human brain tissue, thyroid, hippocampus, thus suggesting a role for proNGF in vivo.5,7,8
Human proNGF Premium Research PackReferences
- Lessman, V. et al. (2003) Prog. Neurobiol. 69, 341.
- Bibel, M. and Barde, Y.A. et al. (2000) Genes Dev. 14, 2929.
- Lee, R. et al. (2001) Science 294, 1945.
- Ibanez, C.F. (2002) Trends Neurosci. 25, 284.
- Hasan, W. et al. (2003) J. Neurobiol. 57, 38.
- Beattie, M.S. et al. (2002) Neuron 36, 375.
- Fahnestock, M. et al. (2001) Mol. Cell. Neurosci. 18, 210.
- Lu, B. (2003) Neuron 39, 735.
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